Quercetin’s Effects on Glutamate Cytotoxicity
The potentially therapeutic effects of the naturally abundant plant flavonoid quercetin have been extensively studied. An extensive body of literature suggests that quercetin’s powerful antioxidant effects may relate to its ability to treat disease. Glutamate excitotoxicity occurs when a neuron is o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/21/7620 |
| _version_ | 1797467065577111552 |
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| author | Kade Riche Natalie R. Lenard |
| author_facet | Kade Riche Natalie R. Lenard |
| author_sort | Kade Riche |
| collection | DOAJ |
| description | The potentially therapeutic effects of the naturally abundant plant flavonoid quercetin have been extensively studied. An extensive body of literature suggests that quercetin’s powerful antioxidant effects may relate to its ability to treat disease. Glutamate excitotoxicity occurs when a neuron is overstimulated by the neurotransmitter glutamate and causes dysregulation of intracellular calcium concentrations. Quercetin has been shown to be preventative against many forms of neuronal cell death resulting from glutamate excitotoxicity, such as oncosis, intrinsic apoptosis, mitochondrial permeability transition, ferroptosis, phagoptosis, lysosomal cell death, parthanatos, and death by reactive oxygen species (ROS)/reactive nitrogen species (RNS) generation. The clinical importance for the attenuation of glutamate excitotoxicity arises from the need to deter the continuous formation of tissue infarction caused by various neurological diseases, such as ischemic stroke, seizures, neurodegenerative diseases, and trauma. This review aims to summarize what is known concerning glutamate physiology and glutamate excitotoxic pathophysiology and provide further insight into quercetin’s potential to hinder neuronal death caused by cell death pathways activated by glutamate excitotoxicity. Quercetin’s bioavailability may limit its use clinically, however. Thus, future research into ways to increase its bioavailability are warranted. |
| first_indexed | 2024-03-09T18:48:20Z |
| format | Article |
| id | doaj.art-d2f6d67e28d4426183be91e66453194c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T18:48:20Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d2f6d67e28d4426183be91e66453194c2023-11-24T06:07:14ZengMDPI AGMolecules1420-30492022-11-012721762010.3390/molecules27217620Quercetin’s Effects on Glutamate CytotoxicityKade Riche0Natalie R. Lenard1Department of Biology, School of Arts and Sciences, Franciscan Missionaries of Our Lady University, 5414 Brittany Drive, Baton Rouge, LA 70808, USADepartment of Biology, School of Arts and Sciences, Franciscan Missionaries of Our Lady University, 5414 Brittany Drive, Baton Rouge, LA 70808, USAThe potentially therapeutic effects of the naturally abundant plant flavonoid quercetin have been extensively studied. An extensive body of literature suggests that quercetin’s powerful antioxidant effects may relate to its ability to treat disease. Glutamate excitotoxicity occurs when a neuron is overstimulated by the neurotransmitter glutamate and causes dysregulation of intracellular calcium concentrations. Quercetin has been shown to be preventative against many forms of neuronal cell death resulting from glutamate excitotoxicity, such as oncosis, intrinsic apoptosis, mitochondrial permeability transition, ferroptosis, phagoptosis, lysosomal cell death, parthanatos, and death by reactive oxygen species (ROS)/reactive nitrogen species (RNS) generation. The clinical importance for the attenuation of glutamate excitotoxicity arises from the need to deter the continuous formation of tissue infarction caused by various neurological diseases, such as ischemic stroke, seizures, neurodegenerative diseases, and trauma. This review aims to summarize what is known concerning glutamate physiology and glutamate excitotoxic pathophysiology and provide further insight into quercetin’s potential to hinder neuronal death caused by cell death pathways activated by glutamate excitotoxicity. Quercetin’s bioavailability may limit its use clinically, however. Thus, future research into ways to increase its bioavailability are warranted.https://www.mdpi.com/1420-3049/27/21/7620glutamateexcitotoxicityreactive oxygen speciesreactive nitrogen species |
| spellingShingle | Kade Riche Natalie R. Lenard Quercetin’s Effects on Glutamate Cytotoxicity Molecules glutamate excitotoxicity reactive oxygen species reactive nitrogen species |
| title | Quercetin’s Effects on Glutamate Cytotoxicity |
| title_full | Quercetin’s Effects on Glutamate Cytotoxicity |
| title_fullStr | Quercetin’s Effects on Glutamate Cytotoxicity |
| title_full_unstemmed | Quercetin’s Effects on Glutamate Cytotoxicity |
| title_short | Quercetin’s Effects on Glutamate Cytotoxicity |
| title_sort | quercetin s effects on glutamate cytotoxicity |
| topic | glutamate excitotoxicity reactive oxygen species reactive nitrogen species |
| url | https://www.mdpi.com/1420-3049/27/21/7620 |
| work_keys_str_mv | AT kaderiche quercetinseffectsonglutamatecytotoxicity AT natalierlenard quercetinseffectsonglutamatecytotoxicity |