Contributions of NR1H3 genetic polymorphisms to susceptibility and effects of narrowband UVB phototherapy to nonsegmental vitiligo
Abstract Vitiligo is the most common depigmenting disorder to which both genetic and environmental factors contribute. The aim of the current work was to evaluate the relationship between polymorphisms of the gene nuclear receptor subfamily 1 Group H member 3 (NR1H3) and the risk of vitiligo and pho...
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| Format: | Article |
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Nature Portfolio
2023-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-30047-7 |
| _version_ | 1797864659863207936 |
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| author | Meifeng Xu Qiuyu Xu Yan Liu Xiaoli Li Mei Wang Wei Dong Yuning Song Shengxiang Xiao |
| author_facet | Meifeng Xu Qiuyu Xu Yan Liu Xiaoli Li Mei Wang Wei Dong Yuning Song Shengxiang Xiao |
| author_sort | Meifeng Xu |
| collection | DOAJ |
| description | Abstract Vitiligo is the most common depigmenting disorder to which both genetic and environmental factors contribute. The aim of the current work was to evaluate the relationship between polymorphisms of the gene nuclear receptor subfamily 1 Group H member 3 (NR1H3) and the risk of vitiligo and phototherapy effects in the Chinese Han population. Two independent samples were enrolled to form the discovery set (comprised of 1668 nonsegmental vitiligo [NSV] patients and 2542 controls) and the validation set (comprised of 745 NSV patients and 1492 controls). A total of 13 tag single nucleotide polymorphisms (SNPs) were genotyped in the samples from the discovery stage. SNPs that achieved nominal significance were validated in another independent sample set. The serum level of NR1H3 protein was assayed using enzyme-linked immunosorbent assay kits in the validation set. Genetic association analysis was carried out at allelic and genotypic levels. The therapeutic effects of significant SNPs were examined in the validation set. The SNP rs3758672 was significantly associated with NSV. The A allele was correlated with NSV risk and poorer therapeutic effects. The A allele was strongly correlated with the increased level of serum NR1H3 in both controls and patients. In summary, SNP rs3758672 in NR1H3 was significantly associated with both disease susceptibility and individualized therapeutic effects of NSV in study participants with Han Chinese ancestry. |
| first_indexed | 2024-04-09T22:55:29Z |
| format | Article |
| id | doaj.art-d2f7cbb08b944c86bcb29c24305bccba |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T22:55:29Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d2f7cbb08b944c86bcb29c24305bccba2023-03-22T11:17:50ZengNature PortfolioScientific Reports2045-23222023-02-011311910.1038/s41598-023-30047-7Contributions of NR1H3 genetic polymorphisms to susceptibility and effects of narrowband UVB phototherapy to nonsegmental vitiligoMeifeng Xu0Qiuyu Xu1Yan Liu2Xiaoli Li3Mei Wang4Wei Dong5Yuning Song6Shengxiang Xiao7Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong UniversitySchool of Medicine and Forensics, Xi’an Jiaotong University Health Science CenterDepartment of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Laboratory Medicine, The Second Affiliated Hospital of Xi’an Jiaotong UniversitySchool of Life Science and Technology, Xi’an Jiaotong UniversityDepartment of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong UniversityAbstract Vitiligo is the most common depigmenting disorder to which both genetic and environmental factors contribute. The aim of the current work was to evaluate the relationship between polymorphisms of the gene nuclear receptor subfamily 1 Group H member 3 (NR1H3) and the risk of vitiligo and phototherapy effects in the Chinese Han population. Two independent samples were enrolled to form the discovery set (comprised of 1668 nonsegmental vitiligo [NSV] patients and 2542 controls) and the validation set (comprised of 745 NSV patients and 1492 controls). A total of 13 tag single nucleotide polymorphisms (SNPs) were genotyped in the samples from the discovery stage. SNPs that achieved nominal significance were validated in another independent sample set. The serum level of NR1H3 protein was assayed using enzyme-linked immunosorbent assay kits in the validation set. Genetic association analysis was carried out at allelic and genotypic levels. The therapeutic effects of significant SNPs were examined in the validation set. The SNP rs3758672 was significantly associated with NSV. The A allele was correlated with NSV risk and poorer therapeutic effects. The A allele was strongly correlated with the increased level of serum NR1H3 in both controls and patients. In summary, SNP rs3758672 in NR1H3 was significantly associated with both disease susceptibility and individualized therapeutic effects of NSV in study participants with Han Chinese ancestry.https://doi.org/10.1038/s41598-023-30047-7 |
| spellingShingle | Meifeng Xu Qiuyu Xu Yan Liu Xiaoli Li Mei Wang Wei Dong Yuning Song Shengxiang Xiao Contributions of NR1H3 genetic polymorphisms to susceptibility and effects of narrowband UVB phototherapy to nonsegmental vitiligo Scientific Reports |
| title | Contributions of NR1H3 genetic polymorphisms to susceptibility and effects of narrowband UVB phototherapy to nonsegmental vitiligo |
| title_full | Contributions of NR1H3 genetic polymorphisms to susceptibility and effects of narrowband UVB phototherapy to nonsegmental vitiligo |
| title_fullStr | Contributions of NR1H3 genetic polymorphisms to susceptibility and effects of narrowband UVB phototherapy to nonsegmental vitiligo |
| title_full_unstemmed | Contributions of NR1H3 genetic polymorphisms to susceptibility and effects of narrowband UVB phototherapy to nonsegmental vitiligo |
| title_short | Contributions of NR1H3 genetic polymorphisms to susceptibility and effects of narrowband UVB phototherapy to nonsegmental vitiligo |
| title_sort | contributions of nr1h3 genetic polymorphisms to susceptibility and effects of narrowband uvb phototherapy to nonsegmental vitiligo |
| url | https://doi.org/10.1038/s41598-023-30047-7 |
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