Oxidation of Benzylic Alcohols and Lignin Model Compounds with Layered Double Hydroxide Catalysts
Alcohol oxidation to carbonyl compounds is one of the most commonly used reactions in synthetic chemistry. Herein, we report the use of base metal layered double hydroxide (LDH) catalysts for the oxidation of benzylic alcohols in polar solvents. These catalysts are ideal reagents for alcohol oxidati...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-07-01
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| Series: | Inorganics |
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| Online Access: | http://www.mdpi.com/2304-6740/6/3/75 |
| _version_ | 1819063172208787456 |
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| author | Justin K. Mobley John A. Jennings Tonya Morgan Axel Kiefer Mark Crocker |
| author_facet | Justin K. Mobley John A. Jennings Tonya Morgan Axel Kiefer Mark Crocker |
| author_sort | Justin K. Mobley |
| collection | DOAJ |
| description | Alcohol oxidation to carbonyl compounds is one of the most commonly used reactions in synthetic chemistry. Herein, we report the use of base metal layered double hydroxide (LDH) catalysts for the oxidation of benzylic alcohols in polar solvents. These catalysts are ideal reagents for alcohol oxidations due to their ease of synthesis, tunability, and ease of separation from the reaction medium. LDHs synthesized in this study were fully characterized by means of X-ray diffraction, NH3-temperature programmed desorption (TPD), pulsed CO2 chemisorption, N2 physisorption, electron microscopy, and elemental analysis. LDHs were found to effectively oxidize benzylic alcohols to their corresponding carbonyl compounds in diphenyl ether, using O2 as the terminal oxidant. LDH catalysts were also applied to the oxidation of lignin β-O-4 model compounds. Typically, for all catalysts, only trace amounts of the ketone formed from benzylic alcohol oxidation were observed, the main products comprising benzoic acids and phenols arising from β-aryl ether cleavage. This observation is consistent with the higher reactivity of the ketones, resulting from weakening of the Cβ–O4 bond that was shown to be aerobically cleaved at 180 °C in the absence of a catalyst. |
| first_indexed | 2024-12-21T15:10:27Z |
| format | Article |
| id | doaj.art-d2f8990d34d64fbebdf3e75f0befe60d |
| institution | Directory Open Access Journal |
| issn | 2304-6740 |
| language | English |
| last_indexed | 2024-12-21T15:10:27Z |
| publishDate | 2018-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Inorganics |
| spelling | doaj.art-d2f8990d34d64fbebdf3e75f0befe60d2022-12-21T18:59:18ZengMDPI AGInorganics2304-67402018-07-01637510.3390/inorganics6030075inorganics6030075Oxidation of Benzylic Alcohols and Lignin Model Compounds with Layered Double Hydroxide CatalystsJustin K. Mobley0John A. Jennings1Tonya Morgan2Axel Kiefer3Mark Crocker4Department of Chemistry, University of Kentucky, Lexington, KY 40506, USADepartment of Chemistry, University of Kentucky, Lexington, KY 40506, USACenter for Applied Energy Research, University of Kentucky, Lexington, KY 40511, USAPaul Laurence Dunbar High School, Lexington, KY 40513, USADepartment of Chemistry, University of Kentucky, Lexington, KY 40506, USAAlcohol oxidation to carbonyl compounds is one of the most commonly used reactions in synthetic chemistry. Herein, we report the use of base metal layered double hydroxide (LDH) catalysts for the oxidation of benzylic alcohols in polar solvents. These catalysts are ideal reagents for alcohol oxidations due to their ease of synthesis, tunability, and ease of separation from the reaction medium. LDHs synthesized in this study were fully characterized by means of X-ray diffraction, NH3-temperature programmed desorption (TPD), pulsed CO2 chemisorption, N2 physisorption, electron microscopy, and elemental analysis. LDHs were found to effectively oxidize benzylic alcohols to their corresponding carbonyl compounds in diphenyl ether, using O2 as the terminal oxidant. LDH catalysts were also applied to the oxidation of lignin β-O-4 model compounds. Typically, for all catalysts, only trace amounts of the ketone formed from benzylic alcohol oxidation were observed, the main products comprising benzoic acids and phenols arising from β-aryl ether cleavage. This observation is consistent with the higher reactivity of the ketones, resulting from weakening of the Cβ–O4 bond that was shown to be aerobically cleaved at 180 °C in the absence of a catalyst.http://www.mdpi.com/2304-6740/6/3/75layered double hydroxidehydrotalcitenickeloxidationbenzylic alcohollignin model compound |
| spellingShingle | Justin K. Mobley John A. Jennings Tonya Morgan Axel Kiefer Mark Crocker Oxidation of Benzylic Alcohols and Lignin Model Compounds with Layered Double Hydroxide Catalysts Inorganics layered double hydroxide hydrotalcite nickel oxidation benzylic alcohol lignin model compound |
| title | Oxidation of Benzylic Alcohols and Lignin Model Compounds with Layered Double Hydroxide Catalysts |
| title_full | Oxidation of Benzylic Alcohols and Lignin Model Compounds with Layered Double Hydroxide Catalysts |
| title_fullStr | Oxidation of Benzylic Alcohols and Lignin Model Compounds with Layered Double Hydroxide Catalysts |
| title_full_unstemmed | Oxidation of Benzylic Alcohols and Lignin Model Compounds with Layered Double Hydroxide Catalysts |
| title_short | Oxidation of Benzylic Alcohols and Lignin Model Compounds with Layered Double Hydroxide Catalysts |
| title_sort | oxidation of benzylic alcohols and lignin model compounds with layered double hydroxide catalysts |
| topic | layered double hydroxide hydrotalcite nickel oxidation benzylic alcohol lignin model compound |
| url | http://www.mdpi.com/2304-6740/6/3/75 |
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