Chromosomal Analysis of Couples with Repeated Spontaneous Abortions in Northeastern Iran
Background Cytogenetic study of reproductive wastage is an important aspect in determining the genetic background of early embryogenesis. Approximately 15 to 20% of all pregnancies in humans are terminated as recurrent spontaneous abortions (RSAs). The aim of this study was to detect chromosome abno...
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| Format: | Article |
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Royan Institute (ACECR), Tehran
2015-04-01
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| Series: | International Journal of Fertility and Sterility |
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| Online Access: | http://www.ijfs.ir/article_45285_69e499da3163085f37141b9a94bce865.pdf |
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| author | Saeedeh Ghazaey Fatemeh Keify Farzaneh Mirzaei Masumeh Maleki Semiramis Tootian Mitra Ahadian Mohammad Reza Abbaszadegan |
| author_facet | Saeedeh Ghazaey Fatemeh Keify Farzaneh Mirzaei Masumeh Maleki Semiramis Tootian Mitra Ahadian Mohammad Reza Abbaszadegan |
| author_sort | Saeedeh Ghazaey |
| collection | DOAJ |
| description | Background Cytogenetic study of reproductive wastage is an important aspect in determining the genetic background of early embryogenesis. Approximately 15 to 20% of all pregnancies in humans are terminated as recurrent spontaneous abortions (RSAs). The aim of this study was to detect chromosome abnormalities in couples with RSAs and to compare our results with those reported previously. Materials and Methods In this retrospective study, the pattern of chromosomal aberrations was evaluated during a six-year period from 2005 to 2011. The population under study was 728 couples who attended genetic counseling services for their RSAs at Pardis Clinical and Genetics Laboratory, Mashhad, Iran. Results In this study, about 11.7% of couples were carriers of chromosomal aberrations. The majority of abnormalities were found in couples with history of abortion, without stillbirth or livebirth. Balanced reciprocal translocations, Robertsonian translocations, inversions and sex chromosome aneuploidy were seen in these cases. Balanced reciprocal translocations were the most frequent chromosomal anomalies (62.7%) detected in current study. Conclusion These findings suggest that chromosomal abnormalities can be one of the important causes of RSAs. In addition, cytogenetic study of families who experienced RSAs may prevent unnecessary treatment if RSA are caused by chromosomal abnormalities. The results of cytogenetic studies of RSA cases will provide a standard protocol for the genetic counselors in order to follow up and to help these families. |
| first_indexed | 2024-12-11T23:21:44Z |
| format | Article |
| id | doaj.art-d2fc5527021f4a1483ca4d4833aab31d |
| institution | Directory Open Access Journal |
| issn | 2008-076X 2008-0778 |
| language | English |
| last_indexed | 2024-12-11T23:21:44Z |
| publishDate | 2015-04-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | International Journal of Fertility and Sterility |
| spelling | doaj.art-d2fc5527021f4a1483ca4d4833aab31d2022-12-22T00:46:20ZengRoyan Institute (ACECR), TehranInternational Journal of Fertility and Sterility2008-076X2008-07782015-04-0191475410.22074/ijfs.2015.420845285Chromosomal Analysis of Couples with Repeated Spontaneous Abortions in Northeastern IranSaeedeh Ghazaey0Fatemeh Keify1Farzaneh Mirzaei2Masumeh Maleki3Semiramis Tootian4Mitra Ahadian5Mohammad Reza Abbaszadegan6Medical Genetics Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran;Pardis Clinical and Genetics Laboratory, Mashhad, IranPardis Clinical and Genetics Laboratory, Mashhad, IranPardis Clinical and Genetics Laboratory, Mashhad, IranPardis Clinical and Genetics Laboratory, Mashhad, IranPardis Clinical and Genetics Laboratory, Mashhad, IranPardis Clinical and Genetics Laboratory, Mashhad, IranPardis Clinical and Genetics Laboratory, Mashhad, Iran;Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, IranBackground Cytogenetic study of reproductive wastage is an important aspect in determining the genetic background of early embryogenesis. Approximately 15 to 20% of all pregnancies in humans are terminated as recurrent spontaneous abortions (RSAs). The aim of this study was to detect chromosome abnormalities in couples with RSAs and to compare our results with those reported previously. Materials and Methods In this retrospective study, the pattern of chromosomal aberrations was evaluated during a six-year period from 2005 to 2011. The population under study was 728 couples who attended genetic counseling services for their RSAs at Pardis Clinical and Genetics Laboratory, Mashhad, Iran. Results In this study, about 11.7% of couples were carriers of chromosomal aberrations. The majority of abnormalities were found in couples with history of abortion, without stillbirth or livebirth. Balanced reciprocal translocations, Robertsonian translocations, inversions and sex chromosome aneuploidy were seen in these cases. Balanced reciprocal translocations were the most frequent chromosomal anomalies (62.7%) detected in current study. Conclusion These findings suggest that chromosomal abnormalities can be one of the important causes of RSAs. In addition, cytogenetic study of families who experienced RSAs may prevent unnecessary treatment if RSA are caused by chromosomal abnormalities. The results of cytogenetic studies of RSA cases will provide a standard protocol for the genetic counselors in order to follow up and to help these families.http://www.ijfs.ir/article_45285_69e499da3163085f37141b9a94bce865.pdfchromosomal abnormalitiesabortionscytogenetic analysis |
| spellingShingle | Saeedeh Ghazaey Fatemeh Keify Farzaneh Mirzaei Masumeh Maleki Semiramis Tootian Mitra Ahadian Mohammad Reza Abbaszadegan Chromosomal Analysis of Couples with Repeated Spontaneous Abortions in Northeastern Iran International Journal of Fertility and Sterility chromosomal abnormalities abortions cytogenetic analysis |
| title | Chromosomal Analysis of Couples with Repeated Spontaneous Abortions in Northeastern Iran |
| title_full | Chromosomal Analysis of Couples with Repeated Spontaneous Abortions in Northeastern Iran |
| title_fullStr | Chromosomal Analysis of Couples with Repeated Spontaneous Abortions in Northeastern Iran |
| title_full_unstemmed | Chromosomal Analysis of Couples with Repeated Spontaneous Abortions in Northeastern Iran |
| title_short | Chromosomal Analysis of Couples with Repeated Spontaneous Abortions in Northeastern Iran |
| title_sort | chromosomal analysis of couples with repeated spontaneous abortions in northeastern iran |
| topic | chromosomal abnormalities abortions cytogenetic analysis |
| url | http://www.ijfs.ir/article_45285_69e499da3163085f37141b9a94bce865.pdf |
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