D2 Receptors and Sodium Ion Channel Blockades of the Basolateral Amygdala Attenuate Lithium Chloride-Induced Conditioned Taste Aversion Applying to Cancer Chemotherapy Nausea and Vomiting
Cancer patients regularly suffer from the behavioral symptoms of chemotherapy-induced nausea and vomiting. Particularly, it is involved in Pavlovian conditioning. Lithium chloride (LiCl) was used as the unconditioned stimulus (US) and contingent with the tastant, for example, a saccharin solution (i...
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MDPI AG
2023-04-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/4/697 |
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| author | Zhi-Yue Gao Chung Ming Huang Cai-N Cheng Andrew Chih-Wei Huang |
| author_facet | Zhi-Yue Gao Chung Ming Huang Cai-N Cheng Andrew Chih-Wei Huang |
| author_sort | Zhi-Yue Gao |
| collection | DOAJ |
| description | Cancer patients regularly suffer from the behavioral symptoms of chemotherapy-induced nausea and vomiting. Particularly, it is involved in Pavlovian conditioning. Lithium chloride (LiCl) was used as the unconditioned stimulus (US) and contingent with the tastant, for example, a saccharin solution (i.e., the conditioned stimulus; CS), resulted in conditioned taste aversion (CTA) to the CS intake. The present study employed an animal model of LiCl-induced CTA to imitate chemotherapy-induced nausea and vomiting symptoms. Recently, the basolateral amygdala (BLA) was shown to mediate LiCl-induced CTA learning; however, which brain mechanisms of the BLA regulate CTA by LiCl remain unknown. The present study was designed to test this issue, and 4% lidocaine or D2 blocker haloperidol were microinjected into BLA between the 0.1% saccharin solution intake and 0.15M LiCl. The results showed lidocaine microinjections into the BLA could attenuate the LiCl-induced CTA. Microinjections of haloperidol blunted the CTA learning by LiCl. Altogether, BLA via the sodium chloride ion channel and D2 receptors control LiCl-induced conditioned saccharin solution intake suppression. The findings can provide some implications and contributions to cancer chemotherapy-induced nausea and vomiting side effects, and will help to develop novel strategies to prevent the side effects of cancer chemotherapy. |
| first_indexed | 2024-03-11T05:11:26Z |
| format | Article |
| id | doaj.art-d2fc9b5c3f3740f18e0df9c23544a2ec |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T05:11:26Z |
| publishDate | 2023-04-01 |
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| spelling | doaj.art-d2fc9b5c3f3740f18e0df9c23544a2ec2023-11-17T18:33:48ZengMDPI AGBrain Sciences2076-34252023-04-0113469710.3390/brainsci13040697D2 Receptors and Sodium Ion Channel Blockades of the Basolateral Amygdala Attenuate Lithium Chloride-Induced Conditioned Taste Aversion Applying to Cancer Chemotherapy Nausea and VomitingZhi-Yue Gao0Chung Ming Huang1Cai-N Cheng2Andrew Chih-Wei Huang3Yuanshan Branch, Taipei Veterans General Hospital, Yi-Lan County 26247, TaiwanDepartment of Psychology, Fo Guang University, Yi-Lan 26247, TaiwanDepartment of Psychology, Fo Guang University, Yi-Lan 26247, TaiwanDepartment of Psychology, Fo Guang University, Yi-Lan 26247, TaiwanCancer patients regularly suffer from the behavioral symptoms of chemotherapy-induced nausea and vomiting. Particularly, it is involved in Pavlovian conditioning. Lithium chloride (LiCl) was used as the unconditioned stimulus (US) and contingent with the tastant, for example, a saccharin solution (i.e., the conditioned stimulus; CS), resulted in conditioned taste aversion (CTA) to the CS intake. The present study employed an animal model of LiCl-induced CTA to imitate chemotherapy-induced nausea and vomiting symptoms. Recently, the basolateral amygdala (BLA) was shown to mediate LiCl-induced CTA learning; however, which brain mechanisms of the BLA regulate CTA by LiCl remain unknown. The present study was designed to test this issue, and 4% lidocaine or D2 blocker haloperidol were microinjected into BLA between the 0.1% saccharin solution intake and 0.15M LiCl. The results showed lidocaine microinjections into the BLA could attenuate the LiCl-induced CTA. Microinjections of haloperidol blunted the CTA learning by LiCl. Altogether, BLA via the sodium chloride ion channel and D2 receptors control LiCl-induced conditioned saccharin solution intake suppression. The findings can provide some implications and contributions to cancer chemotherapy-induced nausea and vomiting side effects, and will help to develop novel strategies to prevent the side effects of cancer chemotherapy.https://www.mdpi.com/2076-3425/13/4/697LiClconditioned taste aversiondopamineD2 receptorsodium ion channel blockerbasolateral amygdala |
| spellingShingle | Zhi-Yue Gao Chung Ming Huang Cai-N Cheng Andrew Chih-Wei Huang D2 Receptors and Sodium Ion Channel Blockades of the Basolateral Amygdala Attenuate Lithium Chloride-Induced Conditioned Taste Aversion Applying to Cancer Chemotherapy Nausea and Vomiting Brain Sciences LiCl conditioned taste aversion dopamine D2 receptor sodium ion channel blocker basolateral amygdala |
| title | D2 Receptors and Sodium Ion Channel Blockades of the Basolateral Amygdala Attenuate Lithium Chloride-Induced Conditioned Taste Aversion Applying to Cancer Chemotherapy Nausea and Vomiting |
| title_full | D2 Receptors and Sodium Ion Channel Blockades of the Basolateral Amygdala Attenuate Lithium Chloride-Induced Conditioned Taste Aversion Applying to Cancer Chemotherapy Nausea and Vomiting |
| title_fullStr | D2 Receptors and Sodium Ion Channel Blockades of the Basolateral Amygdala Attenuate Lithium Chloride-Induced Conditioned Taste Aversion Applying to Cancer Chemotherapy Nausea and Vomiting |
| title_full_unstemmed | D2 Receptors and Sodium Ion Channel Blockades of the Basolateral Amygdala Attenuate Lithium Chloride-Induced Conditioned Taste Aversion Applying to Cancer Chemotherapy Nausea and Vomiting |
| title_short | D2 Receptors and Sodium Ion Channel Blockades of the Basolateral Amygdala Attenuate Lithium Chloride-Induced Conditioned Taste Aversion Applying to Cancer Chemotherapy Nausea and Vomiting |
| title_sort | d2 receptors and sodium ion channel blockades of the basolateral amygdala attenuate lithium chloride induced conditioned taste aversion applying to cancer chemotherapy nausea and vomiting |
| topic | LiCl conditioned taste aversion dopamine D2 receptor sodium ion channel blocker basolateral amygdala |
| url | https://www.mdpi.com/2076-3425/13/4/697 |
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