A systematic review of saliva on its diagnostic utility
Introduction: A paradigm shift in recent years has led to the consideration of the oral cavity (and, thus, oral disease) not in isolation but as a component integrated with systemic physiology, important in maintaining systemic health and reflective of systemic disease. Saliva has been studied exten...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Journal of Dr. NTR University of Health Sciences |
| Subjects: | |
| Online Access: | http://www.jdrntruhs.org/article.asp?issn=2277-8632;year=2018;volume=7;issue=2;spage=115;epage=119;aulast=Mortha |
| _version_ | 1811224725110652928 |
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| author | Neeharika Mortha Divya Uppala Nandita R Kothia Sumit Majumdar Sreekanth Kotina K Sravya |
| author_facet | Neeharika Mortha Divya Uppala Nandita R Kothia Sumit Majumdar Sreekanth Kotina K Sravya |
| author_sort | Neeharika Mortha |
| collection | DOAJ |
| description | Introduction: A paradigm shift in recent years has led to the consideration of the oral cavity (and, thus, oral disease) not in isolation but as a component integrated with systemic physiology, important in maintaining systemic health and reflective of systemic disease. Saliva has been studied extensively as a potential diagnostic tool over the last decade due to its ease and noninvasive accessibility along with its abundance of biomarkers.
Aim and Objective: This is a systematic review of the studies published in past 15 years in electronic databases regarding the utility of saliva as a diagnostic tool. A scrutiny of abundantly studied diagnostic areas using saliva, the analytes of significance, and methodologies was performed.
Materials and Methods: Data collected from electronic databases, followed by data extraction and management.
Results and Conclusion: Eighty-five studies considered among 510 studies represent the evolution of saliva in screening neoplasms, with 34 different analytes detected in this population followed by 22 in metabolic disorders, and the least being in systemic disorders. The most abundantly applied technique is enzyme-linked immunosorbent assay, the common analyte being immunoglobulins. The application of high-throughput proteomic techniques in various studies in the past decade has led to the discovery of new biomarkers. |
| first_indexed | 2024-04-12T08:54:21Z |
| format | Article |
| id | doaj.art-d2ff687dd2df452baaeaa6b1d8b22001 |
| institution | Directory Open Access Journal |
| issn | 2277-8632 |
| language | English |
| last_indexed | 2024-04-12T08:54:21Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Dr. NTR University of Health Sciences |
| spelling | doaj.art-d2ff687dd2df452baaeaa6b1d8b220012022-12-22T03:39:29ZengWolters Kluwer Medknow PublicationsJournal of Dr. NTR University of Health Sciences2277-86322018-01-017211511910.4103/JDRNTRUHS.JDRNTRUHS_91_17A systematic review of saliva on its diagnostic utilityNeeharika MorthaDivya UppalaNandita R KothiaSumit MajumdarSreekanth KotinaK SravyaIntroduction: A paradigm shift in recent years has led to the consideration of the oral cavity (and, thus, oral disease) not in isolation but as a component integrated with systemic physiology, important in maintaining systemic health and reflective of systemic disease. Saliva has been studied extensively as a potential diagnostic tool over the last decade due to its ease and noninvasive accessibility along with its abundance of biomarkers. Aim and Objective: This is a systematic review of the studies published in past 15 years in electronic databases regarding the utility of saliva as a diagnostic tool. A scrutiny of abundantly studied diagnostic areas using saliva, the analytes of significance, and methodologies was performed. Materials and Methods: Data collected from electronic databases, followed by data extraction and management. Results and Conclusion: Eighty-five studies considered among 510 studies represent the evolution of saliva in screening neoplasms, with 34 different analytes detected in this population followed by 22 in metabolic disorders, and the least being in systemic disorders. The most abundantly applied technique is enzyme-linked immunosorbent assay, the common analyte being immunoglobulins. The application of high-throughput proteomic techniques in various studies in the past decade has led to the discovery of new biomarkers.http://www.jdrntruhs.org/article.asp?issn=2277-8632;year=2018;volume=7;issue=2;spage=115;epage=119;aulast=MorthaAnalytesbiomarkersdatabaseoral |
| spellingShingle | Neeharika Mortha Divya Uppala Nandita R Kothia Sumit Majumdar Sreekanth Kotina K Sravya A systematic review of saliva on its diagnostic utility Journal of Dr. NTR University of Health Sciences Analytes biomarkers database oral |
| title | A systematic review of saliva on its diagnostic utility |
| title_full | A systematic review of saliva on its diagnostic utility |
| title_fullStr | A systematic review of saliva on its diagnostic utility |
| title_full_unstemmed | A systematic review of saliva on its diagnostic utility |
| title_short | A systematic review of saliva on its diagnostic utility |
| title_sort | systematic review of saliva on its diagnostic utility |
| topic | Analytes biomarkers database oral |
| url | http://www.jdrntruhs.org/article.asp?issn=2277-8632;year=2018;volume=7;issue=2;spage=115;epage=119;aulast=Mortha |
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