Growth hormone receptor antagonism downregulates ATP-binding cassette transporters contributing to improved drug efficacy against melanoma and hepatocarcinoma in vivo

Growth hormone receptor antagonism downregulates ATP-binding cassette transporters contributing to improved drug efficacy against melanoma and hepatocarcinoma in vivo

Knockdown of GH receptor (GHR) in melanoma cells in vitro downregulates ATP-binding cassette-containing (ABC) transporters and sensitizes them to anti-cancer drug treatments. Here we aimed to determine whether a GHR antagonist (GHRA) could control cancer growth by sensitizing tumors to therapy throu...

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Bibliographic Details
Main Authors: Reetobrata Basu, Yanrong Qian, Samuel Mathes, Joseph Terry, Nathan Arnett, Trent Riddell, Austin Stevens, Kevin Funk, Stephen Bell, Zac Bokal, Courtney Batten, Cole Smith, Isaac Mendez-Gibson, Silvana Duran-Ortiz, Grace Lach, Patricia Alexandra Mora-Criollo, Prateek Kulkarni, Emily Davis, Elizabeth Teaford, Darlene E. Berryman, Edward O. List, Sebastian Neggers, John J. Kopchick
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
growth hormone (GH)
GHA
growth hormone receptor antagonist (GHRA)
melanoma
HCC
ABC transporters
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.936145/full

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