Effects of injection of DEHP on immunoglobulin M (IgM) and hematological parameters of rainbow trout (Oncorhynchus mykiss)
The effects of the plasticizer di (2-ethylhexyl) phthalate (DEHP) were evaluated on immunoglobulin M (IgM) and hematological parameters in male rainbow trout (Oncorhynchus mykiss) for a 10-day experimental period. For this purpose, treatment fish were intraperitoneally injected with 50 mg/kg DEHP al...
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| Format: | Article |
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University of Guilan
2016-09-01
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| Series: | تغذیه آبزیان |
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| Online Access: | https://janb.guilan.ac.ir/article_1365_395d988ac9fc920f224ba6bf9462ff9a.pdf |
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| author | Sohrab Ahmadivand Soheil Eagderi Mazaher Zamani Gandomani |
| author_facet | Sohrab Ahmadivand Soheil Eagderi Mazaher Zamani Gandomani |
| author_sort | Sohrab Ahmadivand |
| collection | DOAJ |
| description | The effects of the plasticizer di (2-ethylhexyl) phthalate (DEHP) were evaluated on immunoglobulin M (IgM) and hematological parameters in male rainbow trout (Oncorhynchus mykiss) for a 10-day experimental period. For this purpose, treatment fish were intraperitoneally injected with 50 mg/kg DEHP along with 500 µL carrier, i.e. olive oil and control one only with 500 µL carrier at 1 and 5 days of experiment after anesthetizing. Based on the results, no significant difference was found between DEHP and control groups regarding IgM levels (P>0.05). The results showed that erythrocyte count and white blood cells were significantly lower in fish exposed to DEHP compared to those of control fish (P<0.05). However, no significant difference was observed in lymphocyte, neutrophils, eosinophils, monocyte, hematocrit, MCHC, MCH and MCV values between the DEHP treatment and control group (P>0.05). In conclusion, our findings suggest adverse effects of DEHP on the immune system which may lead to an increase in disease susceptibility also verify that leukocyte counts can be considered as a novel biomarker of immunotoxicity. |
| first_indexed | 2024-03-12T00:44:35Z |
| format | Article |
| id | doaj.art-d3015af526744fed9288872d04a804e7 |
| institution | Directory Open Access Journal |
| issn | 2980-8499 |
| language | fas |
| last_indexed | 2024-03-12T00:44:35Z |
| publishDate | 2016-09-01 |
| publisher | University of Guilan |
| record_format | Article |
| series | تغذیه آبزیان |
| spelling | doaj.art-d3015af526744fed9288872d04a804e72023-09-14T20:20:52ZfasUniversity of Guilanتغذیه آبزیان2980-84992016-09-0122191365Effects of injection of DEHP on immunoglobulin M (IgM) and hematological parameters of rainbow trout (Oncorhynchus mykiss)Sohrab Ahmadivand0Soheil Eagderi1Mazaher Zamani Gandomani2Department of Aquatic Animal Health, Faculty of Veterinary Medicine, University of Tehran, Tehran, IranDepartment of Fisheries, Faculty of Natural Resources, University of Tehran, Karaj, IranDepartment of Aquatic Animal Health, Faculty of Veterinary Medicine, University of Tehran, Tehran, IranThe effects of the plasticizer di (2-ethylhexyl) phthalate (DEHP) were evaluated on immunoglobulin M (IgM) and hematological parameters in male rainbow trout (Oncorhynchus mykiss) for a 10-day experimental period. For this purpose, treatment fish were intraperitoneally injected with 50 mg/kg DEHP along with 500 µL carrier, i.e. olive oil and control one only with 500 µL carrier at 1 and 5 days of experiment after anesthetizing. Based on the results, no significant difference was found between DEHP and control groups regarding IgM levels (P>0.05). The results showed that erythrocyte count and white blood cells were significantly lower in fish exposed to DEHP compared to those of control fish (P<0.05). However, no significant difference was observed in lymphocyte, neutrophils, eosinophils, monocyte, hematocrit, MCHC, MCH and MCV values between the DEHP treatment and control group (P>0.05). In conclusion, our findings suggest adverse effects of DEHP on the immune system which may lead to an increase in disease susceptibility also verify that leukocyte counts can be considered as a novel biomarker of immunotoxicity.https://janb.guilan.ac.ir/article_1365_395d988ac9fc920f224ba6bf9462ff9a.pdftroutdehpigmhematological indices |
| spellingShingle | Sohrab Ahmadivand Soheil Eagderi Mazaher Zamani Gandomani Effects of injection of DEHP on immunoglobulin M (IgM) and hematological parameters of rainbow trout (Oncorhynchus mykiss) تغذیه آبزیان trout dehp igm hematological indices |
| title | Effects of injection of DEHP on immunoglobulin M (IgM) and hematological parameters of rainbow trout (Oncorhynchus mykiss) |
| title_full | Effects of injection of DEHP on immunoglobulin M (IgM) and hematological parameters of rainbow trout (Oncorhynchus mykiss) |
| title_fullStr | Effects of injection of DEHP on immunoglobulin M (IgM) and hematological parameters of rainbow trout (Oncorhynchus mykiss) |
| title_full_unstemmed | Effects of injection of DEHP on immunoglobulin M (IgM) and hematological parameters of rainbow trout (Oncorhynchus mykiss) |
| title_short | Effects of injection of DEHP on immunoglobulin M (IgM) and hematological parameters of rainbow trout (Oncorhynchus mykiss) |
| title_sort | effects of injection of dehp on immunoglobulin m igm and hematological parameters of rainbow trout oncorhynchus mykiss |
| topic | trout dehp igm hematological indices |
| url | https://janb.guilan.ac.ir/article_1365_395d988ac9fc920f224ba6bf9462ff9a.pdf |
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