A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro

A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro

There is a clear need for novel antiviral concepts to control SARS-CoV-2 infection. Based on the promising anti-coronavirus activity observed for a class of 1,4,4-trisubstituted piperidines, we here conducted a detailed analysis of the structure–activity relationship of these structurally unique inh...

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Bibliographic Details
Main Authors:	Sonia De Castro, Annelies Stevaert, Miguel Maldonado, Adrien Delpal, Julie Vandeput, Benjamin Van Loy, Cecilia Eydoux, Jean-Claude Guillemot, Etienne Decroly, Federico Gago, Bruno Canard, Maria-Jose Camarasa, Sonsoles Velázquez, Lieve Naesens
Format:	Article
Language:	English
Published:	MDPI AG 2022-08-01
Series:	Pharmaceuticals
Subjects:	1,4,4-trisubstituted piperidine Ugi reaction antiviral compound coronavirus SARS-CoV-2 main protease
Online Access:	https://www.mdpi.com/1424-8247/15/8/1021

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