Consistent abnormal activity in the putamen by dopamine modulation in Parkinson’s disease: A resting-state neuroimaging meta-analysis
Objective: This study aimed to elucidate brain areas mediated by oral anti-parkinsonian medicine that consistently show abnormal resting-state activation in PD and to reveal their functional connectivity profiles using meta-analytic approaches. Methods: Searches of the PubMed, Web of Science databas...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-05-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923024000662 |
| _version_ | 1827289846263054336 |
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| author | Danyan Rong Chuan-Peng Hu Jiaying Yang Zhiying Guo Weiguo Liu Miao Yu |
| author_facet | Danyan Rong Chuan-Peng Hu Jiaying Yang Zhiying Guo Weiguo Liu Miao Yu |
| author_sort | Danyan Rong |
| collection | DOAJ |
| description | Objective: This study aimed to elucidate brain areas mediated by oral anti-parkinsonian medicine that consistently show abnormal resting-state activation in PD and to reveal their functional connectivity profiles using meta-analytic approaches. Methods: Searches of the PubMed, Web of Science databases identified 78 neuroimaging studies including PD OFF state (PD-OFF) versus (vs.) PD ON state (PD-ON) or PD-ON versus healthy controls (HCs) or PD-OFF versus HCs data. Coordinate-based meta-analysis and functional meta-analytic connectivity modeling (MACM) were performed using the activation likelihood estimation algorithm. Results: Brain activation in PD-OFF vs. PD-ON was significantly changed in the right putamen and left inferior parietal lobule (IPL). Contrast analysis indicated that PD-OFF vs. HCs had more consistent activation in the right paracentral lobule, right middle frontal gyrus, right thalamus, left superior parietal lobule and right putamen, whereas PD-ON vs. HCs elicited more consistent activation in the bilateral middle temporal gyrus, left occipital gyrus, right inferior frontal gyrus and right caudate. MACM revealed coactivation of the right putamen in the direct contrast of PD-OFF vs. PD-ON. Subtraction analysis of significant coactivation clusters for PD-OFF vs. PD-ON with the medium of HCs showed effects in the sensorimotor, top-down control, and visual networks. By overlapping the MACM maps of the two analytical strategies, we demonstrated that the coactivated brain region focused on the right putamen. Conclusions: The convergence of local brain regions and co-activation neural networks are involved the putamen, suggesting its potential as a specific imaging biomarker to monitor treatment efficacy. Systematic review registration: [https://www.crd.york.ac.uk/PROSPERO/], identifier [CRD CRD42022304150]. |
| first_indexed | 2024-04-24T11:56:56Z |
| format | Article |
| id | doaj.art-d302dbe274c24017b52dca18dd0e6a87 |
| institution | Directory Open Access Journal |
| issn | 1873-2747 |
| language | English |
| last_indexed | 2024-04-24T11:56:56Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj.art-d302dbe274c24017b52dca18dd0e6a872024-04-09T04:12:39ZengElsevierBrain Research Bulletin1873-27472024-05-01210110933Consistent abnormal activity in the putamen by dopamine modulation in Parkinson’s disease: A resting-state neuroimaging meta-analysisDanyan Rong0Chuan-Peng Hu1Jiaying Yang2Zhiying Guo3Weiguo Liu4Miao Yu5Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, No.264, Guangzhou Road, Gulou District, Nanjing, Jiangsu 210029, ChinaSchool of Psychology, Nanjing Normal University, No.122, Ninghai Road, Gulou District, Nanjing, Jiangsu 210024, ChinaDepartment of Public Health, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, No.138, Xianlin Road, Nanjing, Jiangsu 210023, ChinaDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, No.264, Guangzhou Road, Gulou District, Nanjing, Jiangsu 210029, ChinaDepartment of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, No.264, Guangzhou Road, Gulou District, Nanjing, Jiangsu 210029, China; Corresponding authors.Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, No.264, Guangzhou Road, Gulou District, Nanjing, Jiangsu 210029, China; Corresponding authors.Objective: This study aimed to elucidate brain areas mediated by oral anti-parkinsonian medicine that consistently show abnormal resting-state activation in PD and to reveal their functional connectivity profiles using meta-analytic approaches. Methods: Searches of the PubMed, Web of Science databases identified 78 neuroimaging studies including PD OFF state (PD-OFF) versus (vs.) PD ON state (PD-ON) or PD-ON versus healthy controls (HCs) or PD-OFF versus HCs data. Coordinate-based meta-analysis and functional meta-analytic connectivity modeling (MACM) were performed using the activation likelihood estimation algorithm. Results: Brain activation in PD-OFF vs. PD-ON was significantly changed in the right putamen and left inferior parietal lobule (IPL). Contrast analysis indicated that PD-OFF vs. HCs had more consistent activation in the right paracentral lobule, right middle frontal gyrus, right thalamus, left superior parietal lobule and right putamen, whereas PD-ON vs. HCs elicited more consistent activation in the bilateral middle temporal gyrus, left occipital gyrus, right inferior frontal gyrus and right caudate. MACM revealed coactivation of the right putamen in the direct contrast of PD-OFF vs. PD-ON. Subtraction analysis of significant coactivation clusters for PD-OFF vs. PD-ON with the medium of HCs showed effects in the sensorimotor, top-down control, and visual networks. By overlapping the MACM maps of the two analytical strategies, we demonstrated that the coactivated brain region focused on the right putamen. Conclusions: The convergence of local brain regions and co-activation neural networks are involved the putamen, suggesting its potential as a specific imaging biomarker to monitor treatment efficacy. Systematic review registration: [https://www.crd.york.ac.uk/PROSPERO/], identifier [CRD CRD42022304150].http://www.sciencedirect.com/science/article/pii/S0361923024000662Parkinson’s diseaseResting-state functional neuroimagingMeta-analysisOral anti-parkinsonian medication related activated brain areas |
| spellingShingle | Danyan Rong Chuan-Peng Hu Jiaying Yang Zhiying Guo Weiguo Liu Miao Yu Consistent abnormal activity in the putamen by dopamine modulation in Parkinson’s disease: A resting-state neuroimaging meta-analysis Brain Research Bulletin Parkinson’s disease Resting-state functional neuroimaging Meta-analysis Oral anti-parkinsonian medication related activated brain areas |
| title | Consistent abnormal activity in the putamen by dopamine modulation in Parkinson’s disease: A resting-state neuroimaging meta-analysis |
| title_full | Consistent abnormal activity in the putamen by dopamine modulation in Parkinson’s disease: A resting-state neuroimaging meta-analysis |
| title_fullStr | Consistent abnormal activity in the putamen by dopamine modulation in Parkinson’s disease: A resting-state neuroimaging meta-analysis |
| title_full_unstemmed | Consistent abnormal activity in the putamen by dopamine modulation in Parkinson’s disease: A resting-state neuroimaging meta-analysis |
| title_short | Consistent abnormal activity in the putamen by dopamine modulation in Parkinson’s disease: A resting-state neuroimaging meta-analysis |
| title_sort | consistent abnormal activity in the putamen by dopamine modulation in parkinson s disease a resting state neuroimaging meta analysis |
| topic | Parkinson’s disease Resting-state functional neuroimaging Meta-analysis Oral anti-parkinsonian medication related activated brain areas |
| url | http://www.sciencedirect.com/science/article/pii/S0361923024000662 |
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