Effects of beta-alanine supplementation on brain homocarnosine/carnosine signal and cognitive function: an exploratory study.
OBJECTIVES:Two independent studies were conducted to examine the effects of 28 d of beta-alanine supplementation at 6.4 g d(-1) on brain homocarnosine/carnosine signal in omnivores and vegetarians (Study 1) and on cognitive function before and after exercise in trained cyclists (Study 2). METHODS:In...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4397072?pdf=render |
| _version_ | 1818545486710177792 |
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| author | Marina Yazigi Solis Simon Cooper Ruth M Hobson Guilherme G Artioli Maria C Otaduy Hamilton Roschel Jacques Robertson Daniel Martin Vitor S Painelli Roger C Harris Bruno Gualano Craig Sale |
| author_facet | Marina Yazigi Solis Simon Cooper Ruth M Hobson Guilherme G Artioli Maria C Otaduy Hamilton Roschel Jacques Robertson Daniel Martin Vitor S Painelli Roger C Harris Bruno Gualano Craig Sale |
| author_sort | Marina Yazigi Solis |
| collection | DOAJ |
| description | OBJECTIVES:Two independent studies were conducted to examine the effects of 28 d of beta-alanine supplementation at 6.4 g d(-1) on brain homocarnosine/carnosine signal in omnivores and vegetarians (Study 1) and on cognitive function before and after exercise in trained cyclists (Study 2). METHODS:In Study 1, seven healthy vegetarians (3 women and 4 men) and seven age- and sex-matched omnivores undertook a brain 1H-MRS exam at baseline and after beta-alanine supplementation. In study 2, nineteen trained male cyclists completed four 20-Km cycling time trials (two pre supplementation and two post supplementation), with a battery of cognitive function tests (Stroop test, Sternberg paradigm, Rapid Visual Information Processing task) being performed before and after exercise on each occasion. RESULTS:In Study 1, there were no within-group effects of beta-alanine supplementation on brain homocarnosine/carnosine signal in either vegetarians (p = 0.99) or omnivores (p = 0.27); nor was there any effect when data from both groups were pooled (p = 0.19). Similarly, there was no group by time interaction for brain homocarnosine/carnosine signal (p = 0.27). In study 2, exercise improved cognitive function across all tests (P < 0.05), although there was no effect (P>0.05) of beta-alanine supplementation on response times or accuracy for the Stroop test, Sternberg paradigm or RVIP task at rest or after exercise. CONCLUSION:28 d of beta-alanine supplementation at 6.4 g d(-1) appeared not to influence brain homocarnosine/carnosine signal in either omnivores or vegetarians; nor did it influence cognitive function before or after exercise in trained cyclists. |
| first_indexed | 2024-12-12T07:40:49Z |
| format | Article |
| id | doaj.art-d303f9753caf443ab6ad88c8ddd5dd87 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T07:40:49Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d303f9753caf443ab6ad88c8ddd5dd872022-12-22T00:32:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01104e012385710.1371/journal.pone.0123857Effects of beta-alanine supplementation on brain homocarnosine/carnosine signal and cognitive function: an exploratory study.Marina Yazigi SolisSimon CooperRuth M HobsonGuilherme G ArtioliMaria C OtaduyHamilton RoschelJacques RobertsonDaniel MartinVitor S PainelliRoger C HarrisBruno GualanoCraig SaleOBJECTIVES:Two independent studies were conducted to examine the effects of 28 d of beta-alanine supplementation at 6.4 g d(-1) on brain homocarnosine/carnosine signal in omnivores and vegetarians (Study 1) and on cognitive function before and after exercise in trained cyclists (Study 2). METHODS:In Study 1, seven healthy vegetarians (3 women and 4 men) and seven age- and sex-matched omnivores undertook a brain 1H-MRS exam at baseline and after beta-alanine supplementation. In study 2, nineteen trained male cyclists completed four 20-Km cycling time trials (two pre supplementation and two post supplementation), with a battery of cognitive function tests (Stroop test, Sternberg paradigm, Rapid Visual Information Processing task) being performed before and after exercise on each occasion. RESULTS:In Study 1, there were no within-group effects of beta-alanine supplementation on brain homocarnosine/carnosine signal in either vegetarians (p = 0.99) or omnivores (p = 0.27); nor was there any effect when data from both groups were pooled (p = 0.19). Similarly, there was no group by time interaction for brain homocarnosine/carnosine signal (p = 0.27). In study 2, exercise improved cognitive function across all tests (P < 0.05), although there was no effect (P>0.05) of beta-alanine supplementation on response times or accuracy for the Stroop test, Sternberg paradigm or RVIP task at rest or after exercise. CONCLUSION:28 d of beta-alanine supplementation at 6.4 g d(-1) appeared not to influence brain homocarnosine/carnosine signal in either omnivores or vegetarians; nor did it influence cognitive function before or after exercise in trained cyclists.http://europepmc.org/articles/PMC4397072?pdf=render |
| spellingShingle | Marina Yazigi Solis Simon Cooper Ruth M Hobson Guilherme G Artioli Maria C Otaduy Hamilton Roschel Jacques Robertson Daniel Martin Vitor S Painelli Roger C Harris Bruno Gualano Craig Sale Effects of beta-alanine supplementation on brain homocarnosine/carnosine signal and cognitive function: an exploratory study. PLoS ONE |
| title | Effects of beta-alanine supplementation on brain homocarnosine/carnosine signal and cognitive function: an exploratory study. |
| title_full | Effects of beta-alanine supplementation on brain homocarnosine/carnosine signal and cognitive function: an exploratory study. |
| title_fullStr | Effects of beta-alanine supplementation on brain homocarnosine/carnosine signal and cognitive function: an exploratory study. |
| title_full_unstemmed | Effects of beta-alanine supplementation on brain homocarnosine/carnosine signal and cognitive function: an exploratory study. |
| title_short | Effects of beta-alanine supplementation on brain homocarnosine/carnosine signal and cognitive function: an exploratory study. |
| title_sort | effects of beta alanine supplementation on brain homocarnosine carnosine signal and cognitive function an exploratory study |
| url | http://europepmc.org/articles/PMC4397072?pdf=render |
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