<i>Pseudomonas aeruginosa</i> Cytotoxins: Mechanisms of Cytotoxicity and Impact on Inflammatory Responses
<i>Pseudomonas aeruginosa</i> is one of the most virulent opportunistic Gram-negative bacterial pathogens in humans. It causes many acute and chronic infections with morbidity and mortality rates as high as 40%. <i>P. aeruginosa</i> owes its pathogenic versatility to a large...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/1/195 |
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| author | Stephen J. Wood Josef W. Goldufsky Michelle Y. Seu Amir H. Dorafshar Sasha H. Shafikhani |
| author_facet | Stephen J. Wood Josef W. Goldufsky Michelle Y. Seu Amir H. Dorafshar Sasha H. Shafikhani |
| author_sort | Stephen J. Wood |
| collection | DOAJ |
| description | <i>Pseudomonas aeruginosa</i> is one of the most virulent opportunistic Gram-negative bacterial pathogens in humans. It causes many acute and chronic infections with morbidity and mortality rates as high as 40%. <i>P. aeruginosa</i> owes its pathogenic versatility to a large arsenal of cell-associated and secreted virulence factors which enable this pathogen to colonize various niches within hosts and protect it from host innate immune defenses. Induction of cytotoxicity in target host cells is a major virulence strategy for <i>P. aeruginosa</i> during the course of infection. <i>P. aeruginosa</i> has invested heavily in this strategy, as manifested by a plethora of cytotoxins that can induce various forms of cell death in target host cells. In this review, we provide an in-depth review of <i>P. aeruginosa</i> cytotoxins based on their mechanisms of cytotoxicity and the possible consequences of their cytotoxicity on host immune responses. |
| first_indexed | 2024-03-11T10:05:17Z |
| format | Article |
| id | doaj.art-d3042d1e81454b37801ebe86dbc04cf7 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T10:05:17Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-d3042d1e81454b37801ebe86dbc04cf72023-11-16T15:07:25ZengMDPI AGCells2073-44092023-01-0112119510.3390/cells12010195<i>Pseudomonas aeruginosa</i> Cytotoxins: Mechanisms of Cytotoxicity and Impact on Inflammatory ResponsesStephen J. Wood0Josef W. Goldufsky1Michelle Y. Seu2Amir H. Dorafshar3Sasha H. Shafikhani4Department of Medicine, Division of Hematology, Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL 60612, USADepartment of Medicine, Division of Hematology, Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL 60612, USADepartment of Surgery, Division of Plastic and Reconstructive Surgery, Rush University Medical Center, Chicago, IL 60612, USADepartment of Surgery, Division of Plastic and Reconstructive Surgery, Rush University Medical Center, Chicago, IL 60612, USADepartment of Medicine, Division of Hematology, Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL 60612, USA<i>Pseudomonas aeruginosa</i> is one of the most virulent opportunistic Gram-negative bacterial pathogens in humans. It causes many acute and chronic infections with morbidity and mortality rates as high as 40%. <i>P. aeruginosa</i> owes its pathogenic versatility to a large arsenal of cell-associated and secreted virulence factors which enable this pathogen to colonize various niches within hosts and protect it from host innate immune defenses. Induction of cytotoxicity in target host cells is a major virulence strategy for <i>P. aeruginosa</i> during the course of infection. <i>P. aeruginosa</i> has invested heavily in this strategy, as manifested by a plethora of cytotoxins that can induce various forms of cell death in target host cells. In this review, we provide an in-depth review of <i>P. aeruginosa</i> cytotoxins based on their mechanisms of cytotoxicity and the possible consequences of their cytotoxicity on host immune responses.https://www.mdpi.com/2073-4409/12/1/195<i>Pseudomonas aeruginosa</i>infectionvirulence factorscytotoxinsapoptosispyroptosis |
| spellingShingle | Stephen J. Wood Josef W. Goldufsky Michelle Y. Seu Amir H. Dorafshar Sasha H. Shafikhani <i>Pseudomonas aeruginosa</i> Cytotoxins: Mechanisms of Cytotoxicity and Impact on Inflammatory Responses Cells <i>Pseudomonas aeruginosa</i> infection virulence factors cytotoxins apoptosis pyroptosis |
| title | <i>Pseudomonas aeruginosa</i> Cytotoxins: Mechanisms of Cytotoxicity and Impact on Inflammatory Responses |
| title_full | <i>Pseudomonas aeruginosa</i> Cytotoxins: Mechanisms of Cytotoxicity and Impact on Inflammatory Responses |
| title_fullStr | <i>Pseudomonas aeruginosa</i> Cytotoxins: Mechanisms of Cytotoxicity and Impact on Inflammatory Responses |
| title_full_unstemmed | <i>Pseudomonas aeruginosa</i> Cytotoxins: Mechanisms of Cytotoxicity and Impact on Inflammatory Responses |
| title_short | <i>Pseudomonas aeruginosa</i> Cytotoxins: Mechanisms of Cytotoxicity and Impact on Inflammatory Responses |
| title_sort | i pseudomonas aeruginosa i cytotoxins mechanisms of cytotoxicity and impact on inflammatory responses |
| topic | <i>Pseudomonas aeruginosa</i> infection virulence factors cytotoxins apoptosis pyroptosis |
| url | https://www.mdpi.com/2073-4409/12/1/195 |
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