The molecular basis of conformational instability of the ecdysone receptor DNA binding domain studied by in silico and in vitro experiments.

The molecular basis of conformational instability of the ecdysone receptor DNA binding domain studied by in silico and in vitro experiments.

The heterodimer of the ecdysone receptor (EcR) and ultraspiracle (Usp), members of the nuclear receptors superfamily, regulates gene expression associated with molting and metamorphosis in insects. The DNA binding domains (DBDs) of the Usp and EcR play an important role in their DNA-dependent hetero...

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Main Authors: Agnieszka Szamborska-Gbur, Grzegorz Rymarczyk, Marek Orłowski, Tomasz Kuzynowski, Michał Jakób, Agnieszka Dziedzic-Letka, Andrzej Górecki, Piotr Dobryszycki, Andrzej Ożyhar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3900457?pdf=render

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