Assessing genetic diversity and defining signatures of positive selection on the genome of dromedary camels from the southeast of the Arabian Peninsula
Dromedary camels (Camelus dromedarius) are members of the Camelini tribe within the Camelidae family. They are distributed throughout North Africa, the Arabian Peninsula and Southeast Asia. This domestic species is characterized by its superior adaptability to the harsh desert environment. In this s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1296610/full |
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| author | Mohammad Al Abri Ahmad Alfoudari Zainab Mohammad Faisal Almathen Faisal Almathen Waleed Al-Marzooqi Salim Al-Hajri Mahmood Al-Amri Hussain Bahbahani |
| author_facet | Mohammad Al Abri Ahmad Alfoudari Zainab Mohammad Faisal Almathen Faisal Almathen Waleed Al-Marzooqi Salim Al-Hajri Mahmood Al-Amri Hussain Bahbahani |
| author_sort | Mohammad Al Abri |
| collection | DOAJ |
| description | Dromedary camels (Camelus dromedarius) are members of the Camelini tribe within the Camelidae family. They are distributed throughout North Africa, the Arabian Peninsula and Southeast Asia. This domestic species is characterized by its superior adaptability to the harsh desert environment. In this study, whole autosomal data of 29 dromedary samples from the Southeast Arabian Peninsula in Oman; 10 from Muscat, 14 from Al-Batinah, and 5 from Al-Sharqiya, were investigated to assess their genetic relationship and to define candidate signatures of positive selection. A minimal genetic distinction that separates Muscat dromedaries from the other two populations was observed, with a degree of genetic admixture between them. Using the de-correlated composite of multiple signals (DCMS) approach, a total of 47 candidate regions within the autosomes of these dromedary populations were defined with signatures of positive selection. These candidate regions harbor a total of 154 genes that are mainly associated with functional categories related to immune response, lipid metabolism and energy expenditure, optical and auditory functions, and long-term memory. Different functional genomic variants were called on the candidate regions and respective genes that warrant further investigation to find possible association with the different favorable phenotypes in dromedaries. The output of this study paves the way for further research efforts aimed at defining markers for use in genomic breeding programs, with the goal of conserving the genetic diversity of the species and enhancing its productivity. |
| first_indexed | 2024-03-09T14:00:23Z |
| format | Article |
| id | doaj.art-d308934a9ed4489db922666d46e78248 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-03-09T14:00:23Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-d308934a9ed4489db922666d46e782482023-11-30T09:26:19ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-11-011010.3389/fvets.2023.12966101296610Assessing genetic diversity and defining signatures of positive selection on the genome of dromedary camels from the southeast of the Arabian PeninsulaMohammad Al Abri0Ahmad Alfoudari1Zainab Mohammad2Faisal Almathen3Faisal Almathen4Waleed Al-Marzooqi5Salim Al-Hajri6Mahmood Al-Amri7Hussain Bahbahani8Department of Animal and Veterinary Sciences, Sultan Qaboos University, Muscat, OmanDepartment of Biological Sciences, Faculty of Science, Kuwait University, Safat, KuwaitDepartment of Biological Sciences, Faculty of Science, Kuwait University, Safat, KuwaitDepartment of Veterinary Public Health and Animal Husbandry, College of Veterinary Medicine, King Faisal University, Al-Ahsa, Saudi ArabiaCamel Research Center, King Faisal University, Al-Ahsa, Saudi ArabiaDepartment of Animal and Veterinary Sciences, Sultan Qaboos University, Muscat, OmanLaboratories and Research Administration, Directorate General of Veterinary Services, Royal Court Affairs, Muscat, OmanLaboratories and Research Administration, Directorate General of Veterinary Services, Royal Court Affairs, Muscat, OmanDepartment of Biological Sciences, Faculty of Science, Kuwait University, Safat, KuwaitDromedary camels (Camelus dromedarius) are members of the Camelini tribe within the Camelidae family. They are distributed throughout North Africa, the Arabian Peninsula and Southeast Asia. This domestic species is characterized by its superior adaptability to the harsh desert environment. In this study, whole autosomal data of 29 dromedary samples from the Southeast Arabian Peninsula in Oman; 10 from Muscat, 14 from Al-Batinah, and 5 from Al-Sharqiya, were investigated to assess their genetic relationship and to define candidate signatures of positive selection. A minimal genetic distinction that separates Muscat dromedaries from the other two populations was observed, with a degree of genetic admixture between them. Using the de-correlated composite of multiple signals (DCMS) approach, a total of 47 candidate regions within the autosomes of these dromedary populations were defined with signatures of positive selection. These candidate regions harbor a total of 154 genes that are mainly associated with functional categories related to immune response, lipid metabolism and energy expenditure, optical and auditory functions, and long-term memory. Different functional genomic variants were called on the candidate regions and respective genes that warrant further investigation to find possible association with the different favorable phenotypes in dromedaries. The output of this study paves the way for further research efforts aimed at defining markers for use in genomic breeding programs, with the goal of conserving the genetic diversity of the species and enhancing its productivity.https://www.frontiersin.org/articles/10.3389/fvets.2023.1296610/fullde-correlated composite of multiple signalsenvironmental adaptationsignatures of selectiongenetic diversitydromedary camels |
| spellingShingle | Mohammad Al Abri Ahmad Alfoudari Zainab Mohammad Faisal Almathen Faisal Almathen Waleed Al-Marzooqi Salim Al-Hajri Mahmood Al-Amri Hussain Bahbahani Assessing genetic diversity and defining signatures of positive selection on the genome of dromedary camels from the southeast of the Arabian Peninsula Frontiers in Veterinary Science de-correlated composite of multiple signals environmental adaptation signatures of selection genetic diversity dromedary camels |
| title | Assessing genetic diversity and defining signatures of positive selection on the genome of dromedary camels from the southeast of the Arabian Peninsula |
| title_full | Assessing genetic diversity and defining signatures of positive selection on the genome of dromedary camels from the southeast of the Arabian Peninsula |
| title_fullStr | Assessing genetic diversity and defining signatures of positive selection on the genome of dromedary camels from the southeast of the Arabian Peninsula |
| title_full_unstemmed | Assessing genetic diversity and defining signatures of positive selection on the genome of dromedary camels from the southeast of the Arabian Peninsula |
| title_short | Assessing genetic diversity and defining signatures of positive selection on the genome of dromedary camels from the southeast of the Arabian Peninsula |
| title_sort | assessing genetic diversity and defining signatures of positive selection on the genome of dromedary camels from the southeast of the arabian peninsula |
| topic | de-correlated composite of multiple signals environmental adaptation signatures of selection genetic diversity dromedary camels |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1296610/full |
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