The relationship between cannabis use and taurine: A MRS and metabolomics study
Taurine is an essential amino acid. It has been shown to be neuroprotective including protecting against the neurotoxic effects of glutamate. The goal of the current study was to examine the relationship between CB use and taurine measured in brain using magnetic resonance spectroscopy (MRS), and pe...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162360/?tool=EBI |
| _version_ | 1811336229965266944 |
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| author | Sharlene D. Newman Ashley M. Schnakenberg Martin David Raymond Hu Cheng Landon Wilson Stephen Barnes Brian F. O’Donnell |
| author_facet | Sharlene D. Newman Ashley M. Schnakenberg Martin David Raymond Hu Cheng Landon Wilson Stephen Barnes Brian F. O’Donnell |
| author_sort | Sharlene D. Newman |
| collection | DOAJ |
| description | Taurine is an essential amino acid. It has been shown to be neuroprotective including protecting against the neurotoxic effects of glutamate. The goal of the current study was to examine the relationship between CB use and taurine measured in brain using magnetic resonance spectroscopy (MRS), and peripherally from a urine sample. Two experiments are presented. The first is a reanalysis of published data that examined taurine and glutamate in the dorsal anterior cingulate of a CB user group and non-user group using MRS. The second experiment, in a separate CB user group, used metabolomics analysis to measure taurine levels in urine. Because body composition has been associated with the pharmacokinetics of cannabis and taurine levels, a moderation model was examined with body composition included as the covariate. The MRS study found taurine levels were correlated with glutamate in both groups and taurine was correlated with frequency of CB use in the CB user group. The moderation model demonstrated significant effects of CB use and BMI; the interaction was marginally significant with lower BMI individuals showing a positive relationship between CB use and taurine. A similar finding was observed for the urine analysis. Both CB use and weight, as well as the interaction were significant. In this case, individuals with higher weight showed an association between CB use and taurine levels. This study shows the feasibility and potential importance of examining the relationship between taurine and CB use as it may shed light on a mechanism that underlies the neuroprotective effects of CB. |
| first_indexed | 2024-04-13T17:36:26Z |
| format | Article |
| id | doaj.art-d308c7b3d3404b628ed0feb9045d2901 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T17:36:26Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d308c7b3d3404b628ed0feb9045d29012022-12-22T02:37:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01176The relationship between cannabis use and taurine: A MRS and metabolomics studySharlene D. NewmanAshley M. Schnakenberg MartinDavid RaymondHu ChengLandon WilsonStephen BarnesBrian F. O’DonnellTaurine is an essential amino acid. It has been shown to be neuroprotective including protecting against the neurotoxic effects of glutamate. The goal of the current study was to examine the relationship between CB use and taurine measured in brain using magnetic resonance spectroscopy (MRS), and peripherally from a urine sample. Two experiments are presented. The first is a reanalysis of published data that examined taurine and glutamate in the dorsal anterior cingulate of a CB user group and non-user group using MRS. The second experiment, in a separate CB user group, used metabolomics analysis to measure taurine levels in urine. Because body composition has been associated with the pharmacokinetics of cannabis and taurine levels, a moderation model was examined with body composition included as the covariate. The MRS study found taurine levels were correlated with glutamate in both groups and taurine was correlated with frequency of CB use in the CB user group. The moderation model demonstrated significant effects of CB use and BMI; the interaction was marginally significant with lower BMI individuals showing a positive relationship between CB use and taurine. A similar finding was observed for the urine analysis. Both CB use and weight, as well as the interaction were significant. In this case, individuals with higher weight showed an association between CB use and taurine levels. This study shows the feasibility and potential importance of examining the relationship between taurine and CB use as it may shed light on a mechanism that underlies the neuroprotective effects of CB.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162360/?tool=EBI |
| spellingShingle | Sharlene D. Newman Ashley M. Schnakenberg Martin David Raymond Hu Cheng Landon Wilson Stephen Barnes Brian F. O’Donnell The relationship between cannabis use and taurine: A MRS and metabolomics study PLoS ONE |
| title | The relationship between cannabis use and taurine: A MRS and metabolomics study |
| title_full | The relationship between cannabis use and taurine: A MRS and metabolomics study |
| title_fullStr | The relationship between cannabis use and taurine: A MRS and metabolomics study |
| title_full_unstemmed | The relationship between cannabis use and taurine: A MRS and metabolomics study |
| title_short | The relationship between cannabis use and taurine: A MRS and metabolomics study |
| title_sort | relationship between cannabis use and taurine a mrs and metabolomics study |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162360/?tool=EBI |
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