Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study
Abstract Appendicular lean mass (ALM) associates with mobility and bone mineral density (BMD). While associations between gut microbiota composition and ALM have been reported, previous studies rely on relatively small sample sizes. Here, we determine the associations between prevalent gut microbes...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37978-9 |
| _version_ | 1797840957884858368 |
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| author | Louise Grahnemo Maria Nethander Eivind Coward Maiken Elvestad Gabrielsen Satya Sree Jean-Marc Billod Klara Sjögren Lars Engstrand Koen F. Dekkers Tove Fall Arnulf Langhammer Kristian Hveem Claes Ohlsson |
| author_facet | Louise Grahnemo Maria Nethander Eivind Coward Maiken Elvestad Gabrielsen Satya Sree Jean-Marc Billod Klara Sjögren Lars Engstrand Koen F. Dekkers Tove Fall Arnulf Langhammer Kristian Hveem Claes Ohlsson |
| author_sort | Louise Grahnemo |
| collection | DOAJ |
| description | Abstract Appendicular lean mass (ALM) associates with mobility and bone mineral density (BMD). While associations between gut microbiota composition and ALM have been reported, previous studies rely on relatively small sample sizes. Here, we determine the associations between prevalent gut microbes and ALM in large discovery and replication cohorts with information on relevant confounders within the population-based Norwegian HUNT cohort (n = 5196, including women and men). We show that the presence of three bacterial species – Coprococcus comes, Dorea longicatena, and Eubacterium ventriosum – are reproducibly associated with higher ALM. When combined into an anabolic species count, participants with all three anabolic species have 0.80 kg higher ALM than those without any. In an exploratory analysis, the anabolic species count is positively associated with femoral neck and total hip BMD. We conclude that the anabolic species count may be used as a marker of ALM and BMD. The therapeutic potential of these anabolic species to prevent sarcopenia and osteoporosis needs to be determined. |
| first_indexed | 2024-04-09T16:23:14Z |
| format | Article |
| id | doaj.art-d30a16663e9947259168d15d7621fb68 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T16:23:14Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d30a16663e9947259168d15d7621fb682023-04-23T11:22:22ZengNature PortfolioNature Communications2041-17232023-04-011411910.1038/s41467-023-37978-9Identification of three bacterial species associated with increased appendicular lean mass: the HUNT studyLouise Grahnemo0Maria Nethander1Eivind Coward2Maiken Elvestad Gabrielsen3Satya Sree4Jean-Marc Billod5Klara Sjögren6Lars Engstrand7Koen F. Dekkers8Tove Fall9Arnulf Langhammer10Kristian Hveem11Claes Ohlsson12Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of GothenburgDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of GothenburgK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and TechnologyK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and TechnologyBio-Me, Oslo Science ParkBio-Me, Oslo Science ParkDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of GothenburgDepartment of Microbiology, Tumor and Cell Biology, Centre for Translational Microbiome Research, Karolinska Institutet, Karolinska Hospital, Biomedicum A8Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala UniversityDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala UniversityHUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and TechnologyK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and TechnologyDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of GothenburgAbstract Appendicular lean mass (ALM) associates with mobility and bone mineral density (BMD). While associations between gut microbiota composition and ALM have been reported, previous studies rely on relatively small sample sizes. Here, we determine the associations between prevalent gut microbes and ALM in large discovery and replication cohorts with information on relevant confounders within the population-based Norwegian HUNT cohort (n = 5196, including women and men). We show that the presence of three bacterial species – Coprococcus comes, Dorea longicatena, and Eubacterium ventriosum – are reproducibly associated with higher ALM. When combined into an anabolic species count, participants with all three anabolic species have 0.80 kg higher ALM than those without any. In an exploratory analysis, the anabolic species count is positively associated with femoral neck and total hip BMD. We conclude that the anabolic species count may be used as a marker of ALM and BMD. The therapeutic potential of these anabolic species to prevent sarcopenia and osteoporosis needs to be determined.https://doi.org/10.1038/s41467-023-37978-9 |
| spellingShingle | Louise Grahnemo Maria Nethander Eivind Coward Maiken Elvestad Gabrielsen Satya Sree Jean-Marc Billod Klara Sjögren Lars Engstrand Koen F. Dekkers Tove Fall Arnulf Langhammer Kristian Hveem Claes Ohlsson Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study Nature Communications |
| title | Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study |
| title_full | Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study |
| title_fullStr | Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study |
| title_full_unstemmed | Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study |
| title_short | Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study |
| title_sort | identification of three bacterial species associated with increased appendicular lean mass the hunt study |
| url | https://doi.org/10.1038/s41467-023-37978-9 |
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