Early Urinary Biomarkers in Pediatric Autosomal Dominant Polycystic Kidney Disease (ADPKD): No Evidence in the Interest of Urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL)
Background: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is increasingly diagnosed during childhood by the presence of renal cysts in patients with a positive familial history. No curative treatment is available and early detection and diagnosis confronts pediatricians with the lack of early...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-03-01
|
| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fped.2019.00088/full |
| _version_ | 1819064059978317824 |
|---|---|
| author | Marianthi Tsingos Laura Merlini Marco Solcà Alexandra Goischke Alexandra Wilhelm-Bals Paloma Parvex |
| author_facet | Marianthi Tsingos Laura Merlini Marco Solcà Alexandra Goischke Alexandra Wilhelm-Bals Paloma Parvex |
| author_sort | Marianthi Tsingos |
| collection | DOAJ |
| description | Background: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is increasingly diagnosed during childhood by the presence of renal cysts in patients with a positive familial history. No curative treatment is available and early detection and diagnosis confronts pediatricians with the lack of early markers to decide whether to introduce renal-protective agents and prevent the progression of renal failure. Neutrophil Gelatinase-Associated Lipocalin (NGAL) is a tubular protein that has been recently proposed as an early biomarker of renal impairment in the ADPKD adult population.Methods: Urinary NGAL (uNGAL) levels were measured in 15 ADPKD children and compared with 15 age and gender matched controls using parametric, non-parametric, and Bayesian statistics. We also tested the association of uNGAL levels with markers of disease progression, such as proteinuria, albuminuria, blood pressure, and Total Kidney Volume (TKV) using correlation analysis. TKV was calculated by ultrasound, using the ellipsoid method.Results: No difference in mean uNGAL levels was observed between groups (ADPKD: 26.36 ng/ml; Controls: 27.24 ng/ml; P = 0.96). Moreover, no correlation was found between uNGAL and proteinuria (P = 0.51), albuminuria (P = 0.69), TKV (P = 0.68), or mean arterial pressure (P = 0.90). By contrast, TKV was positively correlated with proteinuria (P = 0.04), albuminuria (P = 0.001), and mean arterial pressure (P = 0.03).Conclusion: uNGAL did not confirm its superiority as a marker of disease progression in a pediatric ADPKD population. In the contrary, TKV appears to be an easy measurable variable and may be promising as a surrogate marker to follow ADPKD progression in children. |
| first_indexed | 2024-12-21T15:24:33Z |
| format | Article |
| id | doaj.art-d30b2e7edd044e29a8661a118c2ce49d |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-21T15:24:33Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-d30b2e7edd044e29a8661a118c2ce49d2022-12-21T18:58:57ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602019-03-01710.3389/fped.2019.00088441811Early Urinary Biomarkers in Pediatric Autosomal Dominant Polycystic Kidney Disease (ADPKD): No Evidence in the Interest of Urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL)Marianthi Tsingos0Laura Merlini1Marco Solcà2Alexandra Goischke3Alexandra Wilhelm-Bals4Paloma Parvex5Pediatric Nephrology Unit, Department of Pediatrics, Children's Hospital, Geneva University Hospital, Geneva, SwitzerlandPediatric Radiology Unit, Department of Radiology, Children's Hospital, Geneva University Hospital, Geneva, SwitzerlandLaboratory of Cognitive Neuroscience, Brain Mind Institute and Center for Neuroprosthetics, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Geneva, SwitzerlandPediatric Nephrology Unit, Department of Pediatrics, Children's Hospital, Geneva University Hospital, Geneva, SwitzerlandPediatric Nephrology Unit, Department of Pediatrics, Children's Hospital, Geneva University Hospital, Geneva, SwitzerlandPediatric Nephrology Unit, Department of Pediatrics, Children's Hospital, Geneva University Hospital, Geneva, SwitzerlandBackground: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is increasingly diagnosed during childhood by the presence of renal cysts in patients with a positive familial history. No curative treatment is available and early detection and diagnosis confronts pediatricians with the lack of early markers to decide whether to introduce renal-protective agents and prevent the progression of renal failure. Neutrophil Gelatinase-Associated Lipocalin (NGAL) is a tubular protein that has been recently proposed as an early biomarker of renal impairment in the ADPKD adult population.Methods: Urinary NGAL (uNGAL) levels were measured in 15 ADPKD children and compared with 15 age and gender matched controls using parametric, non-parametric, and Bayesian statistics. We also tested the association of uNGAL levels with markers of disease progression, such as proteinuria, albuminuria, blood pressure, and Total Kidney Volume (TKV) using correlation analysis. TKV was calculated by ultrasound, using the ellipsoid method.Results: No difference in mean uNGAL levels was observed between groups (ADPKD: 26.36 ng/ml; Controls: 27.24 ng/ml; P = 0.96). Moreover, no correlation was found between uNGAL and proteinuria (P = 0.51), albuminuria (P = 0.69), TKV (P = 0.68), or mean arterial pressure (P = 0.90). By contrast, TKV was positively correlated with proteinuria (P = 0.04), albuminuria (P = 0.001), and mean arterial pressure (P = 0.03).Conclusion: uNGAL did not confirm its superiority as a marker of disease progression in a pediatric ADPKD population. In the contrary, TKV appears to be an easy measurable variable and may be promising as a surrogate marker to follow ADPKD progression in children.https://www.frontiersin.org/article/10.3389/fped.2019.00088/fullADPKDuNGALchildrenrenal impairmentTKV |
| spellingShingle | Marianthi Tsingos Laura Merlini Marco Solcà Alexandra Goischke Alexandra Wilhelm-Bals Paloma Parvex Early Urinary Biomarkers in Pediatric Autosomal Dominant Polycystic Kidney Disease (ADPKD): No Evidence in the Interest of Urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) Frontiers in Pediatrics ADPKD uNGAL children renal impairment TKV |
| title | Early Urinary Biomarkers in Pediatric Autosomal Dominant Polycystic Kidney Disease (ADPKD): No Evidence in the Interest of Urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) |
| title_full | Early Urinary Biomarkers in Pediatric Autosomal Dominant Polycystic Kidney Disease (ADPKD): No Evidence in the Interest of Urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) |
| title_fullStr | Early Urinary Biomarkers in Pediatric Autosomal Dominant Polycystic Kidney Disease (ADPKD): No Evidence in the Interest of Urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) |
| title_full_unstemmed | Early Urinary Biomarkers in Pediatric Autosomal Dominant Polycystic Kidney Disease (ADPKD): No Evidence in the Interest of Urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) |
| title_short | Early Urinary Biomarkers in Pediatric Autosomal Dominant Polycystic Kidney Disease (ADPKD): No Evidence in the Interest of Urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) |
| title_sort | early urinary biomarkers in pediatric autosomal dominant polycystic kidney disease adpkd no evidence in the interest of urinary neutrophil gelatinase associated lipocalin ungal |
| topic | ADPKD uNGAL children renal impairment TKV |
| url | https://www.frontiersin.org/article/10.3389/fped.2019.00088/full |
| work_keys_str_mv | AT marianthitsingos earlyurinarybiomarkersinpediatricautosomaldominantpolycystickidneydiseaseadpkdnoevidenceintheinterestofurinaryneutrophilgelatinaseassociatedlipocalinungal AT lauramerlini earlyurinarybiomarkersinpediatricautosomaldominantpolycystickidneydiseaseadpkdnoevidenceintheinterestofurinaryneutrophilgelatinaseassociatedlipocalinungal AT marcosolca earlyurinarybiomarkersinpediatricautosomaldominantpolycystickidneydiseaseadpkdnoevidenceintheinterestofurinaryneutrophilgelatinaseassociatedlipocalinungal AT alexandragoischke earlyurinarybiomarkersinpediatricautosomaldominantpolycystickidneydiseaseadpkdnoevidenceintheinterestofurinaryneutrophilgelatinaseassociatedlipocalinungal AT alexandrawilhelmbals earlyurinarybiomarkersinpediatricautosomaldominantpolycystickidneydiseaseadpkdnoevidenceintheinterestofurinaryneutrophilgelatinaseassociatedlipocalinungal AT palomaparvex earlyurinarybiomarkersinpediatricautosomaldominantpolycystickidneydiseaseadpkdnoevidenceintheinterestofurinaryneutrophilgelatinaseassociatedlipocalinungal |