Impact of oral administration of single strain Lactococcus lactis spp. cremoris on immune responses to keyhole limpet hemocyanin immunization and gut microbiota: A randomized placebo-controlled trial in healthy volunteers

Impact of oral administration of single strain Lactococcus lactis spp. cremoris on immune responses to keyhole limpet hemocyanin immunization and gut microbiota: A randomized placebo-controlled trial in healthy volunteers

IntroductionLactococcus lactis spp. cremoris has been associated with promising immunomodulatory results in preclinical trials. The aim of this study was to investigate the pharmacodynamic (PD) effects of three monoclonal microbial formulations of L. lactis spp. cremoris (EDP1066) on the immune resp...

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Bibliographic Details
Main Authors: Mahdi Saghari, Pim Gal, Hendrika W. Grievink, Erica S. Klaassen, Andrea Itano, Duncan McHale, Matthijs Moerland
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
EDP1066
Lactococcus lactis spp. cremoris
gastrointestinal microbiome
keyhole limpet hemocyanin
late-phase skin reaction
delayed-type hypersensitivity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1009304/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1009304/full

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