Synthesis of New Pt(II) Complex Bearing Organoselenium Ligands and Evaluation of Cytotoxic Activity of Some Structurally Related Pd(II) Complexes

Synthesis of New Pt(II) Complex Bearing Organoselenium Ligands and Evaluation of Cytotoxic Activity of Some Structurally Related Pd(II) Complexes

Herein we report the synthesis of new trans-bis(2-phenylselenylmethyl)oxolane)dichloroplatinum(II) complex Pt1. Newly synthetized complex, together with two, structurally related trans-Pd(II) complexes (trans-bis(2-(phenylselenylmethyl)oxolane)dichloropalladium(II) Pd1 and trans-bis(2-(phenylselenyl...

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Bibliographic Details
Main Authors: Ninko Radenković, Marina Kostić, Nataša Đorđević, Zana Doličanin, Tanja Soldatović, Marko Živanović, Vera M Divac
Format: Article
Language:English
Published: Society of Chemists and Technologists of Macedonia 2020-05-01
Series:Macedonian Journal of Chemistry and Chemical Engineering
Subjects:
organoselenium chemistry
palladium
platinum
cytotoxic activity
colon carcinoma
Online Access:https://mjcce.org.mk/index.php/MJCCE/article/view/1905
Description
Summary:Herein we report the synthesis of new trans-bis(2-phenylselenylmethyl)oxolane)dichloroplatinum(II) complex Pt1. Newly synthetized complex, together with two, structurally related trans-Pd(II) complexes (trans-bis(2-(phenylselenylmethyl)oxolane)dichloropalladium(II) Pd1 and trans-bis(2-(phenylselenylmethyl)oxane)dichloropalladium(II)) Pd2, were screened for cytotoxic activity through in vitro study on the HCT-116 colorectal carcinoma cell line and on the MRC-5 healthy lung pleura cell line. Activity of complexes was assessed by comparing it to the cisplatin. The cells viability and proliferation were determined using MTT assay.
ISSN:1857-5552
1857-5625

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