The Ubiquitin–Proteasome System in Tumor Metabolism
Metabolic reprogramming, which is considered a hallmark of cancer, can maintain the homeostasis of the tumor environment and promote the proliferation, survival, and metastasis of cancer cells. For instance, increased glucose uptake and high glucose consumption, known as the “Warburg effect,” play a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/8/2385 |
| _version_ | 1797606024260091904 |
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| author | Jie Wang Yuandi Xiang Mengqi Fan Shizhen Fang Qingquan Hua |
| author_facet | Jie Wang Yuandi Xiang Mengqi Fan Shizhen Fang Qingquan Hua |
| author_sort | Jie Wang |
| collection | DOAJ |
| description | Metabolic reprogramming, which is considered a hallmark of cancer, can maintain the homeostasis of the tumor environment and promote the proliferation, survival, and metastasis of cancer cells. For instance, increased glucose uptake and high glucose consumption, known as the “Warburg effect,” play an essential part in tumor metabolic reprogramming. In addition, fatty acids are harnessed to satisfy the increased requirement for the phospholipid components of biological membranes and energy. Moreover, the anabolism/catabolism of amino acids, such as glutamine, cystine, and serine, provides nitrogen donors for biosynthesis processes, development of the tumor inflammatory environment, and signal transduction. The ubiquitin–proteasome system (UPS) has been widely reported to be involved in various cellular biological activities. A potential role of UPS in the metabolic regulation of tumor cells has also been reported, but the specific regulatory mechanism has not been elucidated. Here, we review the role of ubiquitination and deubiquitination modification on major metabolic enzymes and important signaling pathways in tumor metabolism to inspire new strategies for the clinical treatment of cancer. |
| first_indexed | 2024-03-11T05:09:31Z |
| format | Article |
| id | doaj.art-d30ff96251f141bf8144616767fbd724 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T05:09:31Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-d30ff96251f141bf8144616767fbd7242023-11-17T18:40:14ZengMDPI AGCancers2072-66942023-04-01158238510.3390/cancers15082385The Ubiquitin–Proteasome System in Tumor MetabolismJie Wang0Yuandi Xiang1Mengqi Fan2Shizhen Fang3Qingquan Hua4Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaMetabolic reprogramming, which is considered a hallmark of cancer, can maintain the homeostasis of the tumor environment and promote the proliferation, survival, and metastasis of cancer cells. For instance, increased glucose uptake and high glucose consumption, known as the “Warburg effect,” play an essential part in tumor metabolic reprogramming. In addition, fatty acids are harnessed to satisfy the increased requirement for the phospholipid components of biological membranes and energy. Moreover, the anabolism/catabolism of amino acids, such as glutamine, cystine, and serine, provides nitrogen donors for biosynthesis processes, development of the tumor inflammatory environment, and signal transduction. The ubiquitin–proteasome system (UPS) has been widely reported to be involved in various cellular biological activities. A potential role of UPS in the metabolic regulation of tumor cells has also been reported, but the specific regulatory mechanism has not been elucidated. Here, we review the role of ubiquitination and deubiquitination modification on major metabolic enzymes and important signaling pathways in tumor metabolism to inspire new strategies for the clinical treatment of cancer.https://www.mdpi.com/2072-6694/15/8/2385metabolismubiquitin–proteasome system modificationtumorsignaling pathwaytreatment |
| spellingShingle | Jie Wang Yuandi Xiang Mengqi Fan Shizhen Fang Qingquan Hua The Ubiquitin–Proteasome System in Tumor Metabolism Cancers metabolism ubiquitin–proteasome system modification tumor signaling pathway treatment |
| title | The Ubiquitin–Proteasome System in Tumor Metabolism |
| title_full | The Ubiquitin–Proteasome System in Tumor Metabolism |
| title_fullStr | The Ubiquitin–Proteasome System in Tumor Metabolism |
| title_full_unstemmed | The Ubiquitin–Proteasome System in Tumor Metabolism |
| title_short | The Ubiquitin–Proteasome System in Tumor Metabolism |
| title_sort | ubiquitin proteasome system in tumor metabolism |
| topic | metabolism ubiquitin–proteasome system modification tumor signaling pathway treatment |
| url | https://www.mdpi.com/2072-6694/15/8/2385 |
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