Decoding Vagus-Nerve Activity with Carbon Nanotube Sensors in Freely Moving Rodents
The vagus nerve is the largest autonomic nerve and a major target of stimulation therapies for a wide variety of chronic diseases. However, chronic recording from the vagus nerve has been limited, leading to significant gaps in our understanding of vagus nerve function and therapeutic mechanisms. In...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/12/2/114 |
| _version_ | 1827656502487285760 |
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| author | Joseph T. Marmerstein Grant A. McCallum Dominique M. Durand |
| author_facet | Joseph T. Marmerstein Grant A. McCallum Dominique M. Durand |
| author_sort | Joseph T. Marmerstein |
| collection | DOAJ |
| description | The vagus nerve is the largest autonomic nerve and a major target of stimulation therapies for a wide variety of chronic diseases. However, chronic recording from the vagus nerve has been limited, leading to significant gaps in our understanding of vagus nerve function and therapeutic mechanisms. In this study, we use a carbon nanotube yarn (CNTY) biosensor to chronically record from the vagus nerves of freely moving rats for over 40 continuous hours. Vagal activity was analyzed using a variety of techniques, such as spike sorting, spike-firing rates, and interspike intervals. Many spike-cluster-firing rates were found to correlate with food intake, and the neural-firing rates were used to classify eating and other behaviors. To our knowledge, this is the first chronic recording and decoding of activity in the vagus nerve of freely moving animals enabled by the axon-like properties of the CNTY biosensor in both size and flexibility and provides an important step forward in our ability to understand spontaneous vagus-nerve function. |
| first_indexed | 2024-03-09T22:28:21Z |
| format | Article |
| id | doaj.art-d310eb2eeb6d49faacee808e476331ee |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T22:28:21Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-d310eb2eeb6d49faacee808e476331ee2023-11-23T19:01:33ZengMDPI AGBiosensors2079-63742022-02-0112211410.3390/bios12020114Decoding Vagus-Nerve Activity with Carbon Nanotube Sensors in Freely Moving RodentsJoseph T. Marmerstein0Grant A. McCallum1Dominique M. Durand2Neural Engineering Center, Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USANeural Engineering Center, Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USANeural Engineering Center, Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USAThe vagus nerve is the largest autonomic nerve and a major target of stimulation therapies for a wide variety of chronic diseases. However, chronic recording from the vagus nerve has been limited, leading to significant gaps in our understanding of vagus nerve function and therapeutic mechanisms. In this study, we use a carbon nanotube yarn (CNTY) biosensor to chronically record from the vagus nerves of freely moving rats for over 40 continuous hours. Vagal activity was analyzed using a variety of techniques, such as spike sorting, spike-firing rates, and interspike intervals. Many spike-cluster-firing rates were found to correlate with food intake, and the neural-firing rates were used to classify eating and other behaviors. To our knowledge, this is the first chronic recording and decoding of activity in the vagus nerve of freely moving animals enabled by the axon-like properties of the CNTY biosensor in both size and flexibility and provides an important step forward in our ability to understand spontaneous vagus-nerve function.https://www.mdpi.com/2079-6374/12/2/114vagus nerveintraneuraldecodingintrafascicularrecordingcarbon nanotube |
| spellingShingle | Joseph T. Marmerstein Grant A. McCallum Dominique M. Durand Decoding Vagus-Nerve Activity with Carbon Nanotube Sensors in Freely Moving Rodents Biosensors vagus nerve intraneural decoding intrafascicular recording carbon nanotube |
| title | Decoding Vagus-Nerve Activity with Carbon Nanotube Sensors in Freely Moving Rodents |
| title_full | Decoding Vagus-Nerve Activity with Carbon Nanotube Sensors in Freely Moving Rodents |
| title_fullStr | Decoding Vagus-Nerve Activity with Carbon Nanotube Sensors in Freely Moving Rodents |
| title_full_unstemmed | Decoding Vagus-Nerve Activity with Carbon Nanotube Sensors in Freely Moving Rodents |
| title_short | Decoding Vagus-Nerve Activity with Carbon Nanotube Sensors in Freely Moving Rodents |
| title_sort | decoding vagus nerve activity with carbon nanotube sensors in freely moving rodents |
| topic | vagus nerve intraneural decoding intrafascicular recording carbon nanotube |
| url | https://www.mdpi.com/2079-6374/12/2/114 |
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