A Review on Electrochemical Sensors and Biosensors Used in Chlorogenic Acid Electroanalysis
Chlorogenic acid (5-O-caffeoylquinic acid) is a phenolic compound from the hydroxycinnamic acid family. Epidemiological, biological, and biochemical studies concur to support the beneficial role of chlorogenic acid in human health, along with other dietary phenolic compounds. Thus, chlorogenic acid...
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| Format: | Article |
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/23/13138 |
| _version_ | 1797507738941521920 |
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| author | Irina Georgiana Munteanu Constantin Apetrei |
| author_facet | Irina Georgiana Munteanu Constantin Apetrei |
| author_sort | Irina Georgiana Munteanu |
| collection | DOAJ |
| description | Chlorogenic acid (5-O-caffeoylquinic acid) is a phenolic compound from the hydroxycinnamic acid family. Epidemiological, biological, and biochemical studies concur to support the beneficial role of chlorogenic acid in human health, along with other dietary phenolic compounds. Thus, chlorogenic acid has been reported to exert inhibitory effects on carcinogenesis in the large intestine, liver, and tongue, and a protective action on oxidative stress in vivo, together with anti-inflammatory, antidiabetic and antihypertensive activities. It is also claimed to have antifungal, antibacterial and antiviral effects with relatively low toxicity and side effects, alongside properties that do not lead to antimicrobial resistance. Due to its importance, numerous methods for determining chlorogenic acid (CGA), as well as for its derivatives from coffee beans and other plants, were elaborated. The most frequently used methods are infrared spectroscopy, high performance liquid chromatography (HPLC), capillary electrophoresis, liquid chromatography-mass spectrometry and chemiluminescence. Although these methods proved to be efficient for quantifying CGA and its derived products, a number of deficiencies were identified: they are time consuming, laborious, and require expensive instruments. Therefore, electrochemical methods have been developed and used in the determination of CGA in different nutraceuticals or food products. The present review aims to present the main progresses and performance characteristics of electrochemical sensors and biosensors used to detect CGA, as it is reported in a high number of relevant scientific papers published mainly in the last decade. |
| first_indexed | 2024-03-10T04:52:45Z |
| format | Article |
| id | doaj.art-d312f39188374a988683ee80b3b72ebc |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:52:45Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d312f39188374a988683ee80b3b72ebc2023-11-23T02:33:54ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-0122231313810.3390/ijms222313138A Review on Electrochemical Sensors and Biosensors Used in Chlorogenic Acid ElectroanalysisIrina Georgiana Munteanu0Constantin Apetrei1Department of Chemistry, Physics and Environment, Faculty of Sciences and Environment, “Dunărea de Jos” University of Galaţi, 47 Domneasca Street, 800008 Galaţi, RomaniaDepartment of Chemistry, Physics and Environment, Faculty of Sciences and Environment, “Dunărea de Jos” University of Galaţi, 47 Domneasca Street, 800008 Galaţi, RomaniaChlorogenic acid (5-O-caffeoylquinic acid) is a phenolic compound from the hydroxycinnamic acid family. Epidemiological, biological, and biochemical studies concur to support the beneficial role of chlorogenic acid in human health, along with other dietary phenolic compounds. Thus, chlorogenic acid has been reported to exert inhibitory effects on carcinogenesis in the large intestine, liver, and tongue, and a protective action on oxidative stress in vivo, together with anti-inflammatory, antidiabetic and antihypertensive activities. It is also claimed to have antifungal, antibacterial and antiviral effects with relatively low toxicity and side effects, alongside properties that do not lead to antimicrobial resistance. Due to its importance, numerous methods for determining chlorogenic acid (CGA), as well as for its derivatives from coffee beans and other plants, were elaborated. The most frequently used methods are infrared spectroscopy, high performance liquid chromatography (HPLC), capillary electrophoresis, liquid chromatography-mass spectrometry and chemiluminescence. Although these methods proved to be efficient for quantifying CGA and its derived products, a number of deficiencies were identified: they are time consuming, laborious, and require expensive instruments. Therefore, electrochemical methods have been developed and used in the determination of CGA in different nutraceuticals or food products. The present review aims to present the main progresses and performance characteristics of electrochemical sensors and biosensors used to detect CGA, as it is reported in a high number of relevant scientific papers published mainly in the last decade.https://www.mdpi.com/1422-0067/22/23/13138chlorogenic acidelectrochemical sensorenzymebiosensorantioxidant activity |
| spellingShingle | Irina Georgiana Munteanu Constantin Apetrei A Review on Electrochemical Sensors and Biosensors Used in Chlorogenic Acid Electroanalysis International Journal of Molecular Sciences chlorogenic acid electrochemical sensor enzyme biosensor antioxidant activity |
| title | A Review on Electrochemical Sensors and Biosensors Used in Chlorogenic Acid Electroanalysis |
| title_full | A Review on Electrochemical Sensors and Biosensors Used in Chlorogenic Acid Electroanalysis |
| title_fullStr | A Review on Electrochemical Sensors and Biosensors Used in Chlorogenic Acid Electroanalysis |
| title_full_unstemmed | A Review on Electrochemical Sensors and Biosensors Used in Chlorogenic Acid Electroanalysis |
| title_short | A Review on Electrochemical Sensors and Biosensors Used in Chlorogenic Acid Electroanalysis |
| title_sort | review on electrochemical sensors and biosensors used in chlorogenic acid electroanalysis |
| topic | chlorogenic acid electrochemical sensor enzyme biosensor antioxidant activity |
| url | https://www.mdpi.com/1422-0067/22/23/13138 |
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