Global mapping of antibiotic resistance rates among clinical isolates of Stenotrophomonas maltophilia: a systematic review and meta-analysis
Abstract Introduction Infections caused by Stenotrophomonas maltophilia are clinically important due to its intrinsic resistance to a broad range of antibiotics. Therefore, selecting the most appropriate antibiotic to treat S. maltophilia infection is a major challenge. Aim The current meta-analysis...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Annals of Clinical Microbiology and Antimicrobials |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12941-024-00685-4 |
| _version_ | 1797247431842201600 |
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| author | Narjess Bostanghadiri Mohammad Sholeh Tahereh Navidifar Leila Dadgar-Zankbar Zahra Elahi Alex van Belkum Davood Darban-Sarokhalil |
| author_facet | Narjess Bostanghadiri Mohammad Sholeh Tahereh Navidifar Leila Dadgar-Zankbar Zahra Elahi Alex van Belkum Davood Darban-Sarokhalil |
| author_sort | Narjess Bostanghadiri |
| collection | DOAJ |
| description | Abstract Introduction Infections caused by Stenotrophomonas maltophilia are clinically important due to its intrinsic resistance to a broad range of antibiotics. Therefore, selecting the most appropriate antibiotic to treat S. maltophilia infection is a major challenge. Aim The current meta-analysis aimed to investigate the global prevalence of antibiotic resistance among S. maltophilia isolates to the develop more effective therapeutic strategies. Method A systematic literature search was performed using the appropriate search syntax after searching Pubmed, Embase, Web of Science and Scopus databases (May 2023). Statistical analysis was performed using Pooled and the random effects model in R and the metafor package. A total of 11,438 articles were retrieved. After a thorough evaluation, 289 studies were finally eligible for inclusion in this systematic review and meta-analysis. Result Present analysis indicated that the highest incidences of resistance were associated with doripenem (97%), cefoxitin (96%), imipenem and cefuroxime (95%), ampicillin (94%), ceftriaxone (92%), aztreonam (91%) and meropenem (90%) which resistance to Carbapenems is intrinsic. The lowest resistance rates were documented for minocycline (3%), cefiderocol (4%). The global resistance rate to TMP-SMX remained constant in two periods before and after 2010 (14.4% vs. 14.6%). A significant increase in resistance to tigecycline and ceftolozane/tazobactam was observed before and after 2010. Conclusions Minocycline and cefiderocol can be considered the preferred treatment options due to low resistance rates, although regional differences in resistance rates to other antibiotics should be considered. The low global prevalence of resistance to TMP-SMX as a first-line treatment for S. maltophilia suggests that it remains an effective treatment option. |
| first_indexed | 2024-04-24T19:58:35Z |
| format | Article |
| id | doaj.art-d313afbb78a74caabbd481896e7f1540 |
| institution | Directory Open Access Journal |
| issn | 1476-0711 |
| language | English |
| last_indexed | 2024-04-24T19:58:35Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Annals of Clinical Microbiology and Antimicrobials |
| spelling | doaj.art-d313afbb78a74caabbd481896e7f15402024-03-24T12:12:57ZengBMCAnnals of Clinical Microbiology and Antimicrobials1476-07112024-03-0123112110.1186/s12941-024-00685-4Global mapping of antibiotic resistance rates among clinical isolates of Stenotrophomonas maltophilia: a systematic review and meta-analysisNarjess Bostanghadiri0Mohammad Sholeh1Tahereh Navidifar2Leila Dadgar-Zankbar3Zahra Elahi4Alex van Belkum5Davood Darban-Sarokhalil6Department of Microbiology, School of Medicine, Iran University of Medical SciencesDepartment of Bacteriology, Pasteur Institute of IranDepartment of Basic Sciences, Shoushtar Faculty of Medical SciencesDepartment of Microbiology, School of Medicine, Iran University of Medical SciencesDepartment of Microbiology, School of Medicine, Iran University of Medical SciencesOpen Innovation & Partnerships, BaseClearDepartment of Microbiology, School of Medicine, Iran University of Medical SciencesAbstract Introduction Infections caused by Stenotrophomonas maltophilia are clinically important due to its intrinsic resistance to a broad range of antibiotics. Therefore, selecting the most appropriate antibiotic to treat S. maltophilia infection is a major challenge. Aim The current meta-analysis aimed to investigate the global prevalence of antibiotic resistance among S. maltophilia isolates to the develop more effective therapeutic strategies. Method A systematic literature search was performed using the appropriate search syntax after searching Pubmed, Embase, Web of Science and Scopus databases (May 2023). Statistical analysis was performed using Pooled and the random effects model in R and the metafor package. A total of 11,438 articles were retrieved. After a thorough evaluation, 289 studies were finally eligible for inclusion in this systematic review and meta-analysis. Result Present analysis indicated that the highest incidences of resistance were associated with doripenem (97%), cefoxitin (96%), imipenem and cefuroxime (95%), ampicillin (94%), ceftriaxone (92%), aztreonam (91%) and meropenem (90%) which resistance to Carbapenems is intrinsic. The lowest resistance rates were documented for minocycline (3%), cefiderocol (4%). The global resistance rate to TMP-SMX remained constant in two periods before and after 2010 (14.4% vs. 14.6%). A significant increase in resistance to tigecycline and ceftolozane/tazobactam was observed before and after 2010. Conclusions Minocycline and cefiderocol can be considered the preferred treatment options due to low resistance rates, although regional differences in resistance rates to other antibiotics should be considered. The low global prevalence of resistance to TMP-SMX as a first-line treatment for S. maltophilia suggests that it remains an effective treatment option.https://doi.org/10.1186/s12941-024-00685-4Stenotrophomonas maltophiliaAntibiotic resistanceGlobal prevalenceSystematic reviewMeta-analysis |
| spellingShingle | Narjess Bostanghadiri Mohammad Sholeh Tahereh Navidifar Leila Dadgar-Zankbar Zahra Elahi Alex van Belkum Davood Darban-Sarokhalil Global mapping of antibiotic resistance rates among clinical isolates of Stenotrophomonas maltophilia: a systematic review and meta-analysis Annals of Clinical Microbiology and Antimicrobials Stenotrophomonas maltophilia Antibiotic resistance Global prevalence Systematic review Meta-analysis |
| title | Global mapping of antibiotic resistance rates among clinical isolates of Stenotrophomonas maltophilia: a systematic review and meta-analysis |
| title_full | Global mapping of antibiotic resistance rates among clinical isolates of Stenotrophomonas maltophilia: a systematic review and meta-analysis |
| title_fullStr | Global mapping of antibiotic resistance rates among clinical isolates of Stenotrophomonas maltophilia: a systematic review and meta-analysis |
| title_full_unstemmed | Global mapping of antibiotic resistance rates among clinical isolates of Stenotrophomonas maltophilia: a systematic review and meta-analysis |
| title_short | Global mapping of antibiotic resistance rates among clinical isolates of Stenotrophomonas maltophilia: a systematic review and meta-analysis |
| title_sort | global mapping of antibiotic resistance rates among clinical isolates of stenotrophomonas maltophilia a systematic review and meta analysis |
| topic | Stenotrophomonas maltophilia Antibiotic resistance Global prevalence Systematic review Meta-analysis |
| url | https://doi.org/10.1186/s12941-024-00685-4 |
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