Proteogenomic analysis of cancer aneuploidy and normal tissues reveals divergent modes of gene regulation across cellular pathways

Proteogenomic analysis of cancer aneuploidy and normal tissues reveals divergent modes of gene regulation across cellular pathways

How cells control gene expression is a fundamental question. The relative contribution of protein-level and RNA-level regulation to this process remains unclear. Here, we perform a proteogenomic analysis of tumors and untransformed cells containing somatic copy number alterations (SCNAs). By reveali...

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Bibliographic Details
Main Authors: Pan Cheng, Xin Zhao, Lizabeth Katsnelson, Elaine M Camacho-Hernandez, Angela Mermerian, Joseph C Mays, Scott M Lippman, Reyna Edith Rosales-Alvarez, Raquel Moya, Jasmine Shwetar, Dominic Grun, David Fenyo, Teresa Davoli
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-09-01
Series:eLife
Subjects:
proteogenomic
aneuploidy
gene expression
protein regulation
cancer
Online Access:https://elifesciences.org/articles/75227

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