Optimizing combination therapy in the management of hypertension: the role of the aliskiren, amlodipine, and hydrochlorothiazide fixed combination
Michael B Hovater,1 Edgar A Jaimes1,2 1Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; 2Department of Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, AL, USA Abstract: High blood pressure is the leading risk...
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2013-06-01
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| Series: | Integrated Blood Pressure Control |
| Online Access: | http://www.dovepress.com/optimizing-combination-therapy-in-the-management-of-hypertension-the-r-a13339 |
| _version_ | 1818043587658514432 |
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| author | Hovater MB Jaimes EA |
| author_facet | Hovater MB Jaimes EA |
| author_sort | Hovater MB |
| collection | DOAJ |
| description | Michael B Hovater,1 Edgar A Jaimes1,2 1Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; 2Department of Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, AL, USA Abstract: High blood pressure is the leading risk factor for death and disability worldwide, and the prevalence is increasing. Effective treatment decreases the risk of adverse events in proportion to blood pressure reduction. Combination antihypertensive therapy reduces blood pressure promptly and effectively. Single-pill combinations reduce the pill burden and improve adherence, efficacy, and tolerability of treatment compared with single drug pills. A significant portion of the hypertensive population will require three drugs for adequate control. The single-pill combination of aliskiren, amlodipine, and hydrochlorothiazide is based on complementary mechanisms of action. Clinical trials have shown it to be a safe and effective treatment for hypertension. This combination is a reasonable choice in clinical practice for patients with hypertension that requires three drugs for effective treatment. Keywords: aliskiren, amlodipine, hydrochlorothiazide, Amturnide, hypertension, combination |
| first_indexed | 2024-12-10T09:04:35Z |
| format | Article |
| id | doaj.art-d31539bcbf2940f5a90a78e26210767d |
| institution | Directory Open Access Journal |
| issn | 1178-7104 |
| language | English |
| last_indexed | 2024-12-10T09:04:35Z |
| publishDate | 2013-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Integrated Blood Pressure Control |
| spelling | doaj.art-d31539bcbf2940f5a90a78e26210767d2022-12-22T01:55:11ZengDove Medical PressIntegrated Blood Pressure Control1178-71042013-06-012013default5967Optimizing combination therapy in the management of hypertension: the role of the aliskiren, amlodipine, and hydrochlorothiazide fixed combinationHovater MBJaimes EAMichael B Hovater,1 Edgar A Jaimes1,2 1Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; 2Department of Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, AL, USA Abstract: High blood pressure is the leading risk factor for death and disability worldwide, and the prevalence is increasing. Effective treatment decreases the risk of adverse events in proportion to blood pressure reduction. Combination antihypertensive therapy reduces blood pressure promptly and effectively. Single-pill combinations reduce the pill burden and improve adherence, efficacy, and tolerability of treatment compared with single drug pills. A significant portion of the hypertensive population will require three drugs for adequate control. The single-pill combination of aliskiren, amlodipine, and hydrochlorothiazide is based on complementary mechanisms of action. Clinical trials have shown it to be a safe and effective treatment for hypertension. This combination is a reasonable choice in clinical practice for patients with hypertension that requires three drugs for effective treatment. Keywords: aliskiren, amlodipine, hydrochlorothiazide, Amturnide, hypertension, combinationhttp://www.dovepress.com/optimizing-combination-therapy-in-the-management-of-hypertension-the-r-a13339 |
| spellingShingle | Hovater MB Jaimes EA Optimizing combination therapy in the management of hypertension: the role of the aliskiren, amlodipine, and hydrochlorothiazide fixed combination Integrated Blood Pressure Control |
| title | Optimizing combination therapy in the management of hypertension: the role of the aliskiren, amlodipine, and hydrochlorothiazide fixed combination |
| title_full | Optimizing combination therapy in the management of hypertension: the role of the aliskiren, amlodipine, and hydrochlorothiazide fixed combination |
| title_fullStr | Optimizing combination therapy in the management of hypertension: the role of the aliskiren, amlodipine, and hydrochlorothiazide fixed combination |
| title_full_unstemmed | Optimizing combination therapy in the management of hypertension: the role of the aliskiren, amlodipine, and hydrochlorothiazide fixed combination |
| title_short | Optimizing combination therapy in the management of hypertension: the role of the aliskiren, amlodipine, and hydrochlorothiazide fixed combination |
| title_sort | optimizing combination therapy in the management of hypertension the role of the aliskiren amlodipine and hydrochlorothiazide fixed combination |
| url | http://www.dovepress.com/optimizing-combination-therapy-in-the-management-of-hypertension-the-r-a13339 |
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