COVID-19 and blood groups: A six-months observational study in Ferrara, Italy
The current literature still gives a little information about the relationships between the ABO blood group system and the immune response to the virus or the different disease outcomes. Hypothesizing the presence of a predisposition by some blood groups to COVID-19, we searched for differences betw...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Hematology Reports |
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| Online Access: | https://www.pagepress.org/journals/index.php/hr/article/view/9177 |
| _version_ | 1828047058038161408 |
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| author | Salvatore Greco Nicolò Fabbri Alessandro Bella Beatrice Bonsi Alessandra Violi Valeria Fortunato Maurizio Govoni Giuseppe Graldi Angelina Passaro |
| author_facet | Salvatore Greco Nicolò Fabbri Alessandro Bella Beatrice Bonsi Alessandra Violi Valeria Fortunato Maurizio Govoni Giuseppe Graldi Angelina Passaro |
| author_sort | Salvatore Greco |
| collection | DOAJ |
| description | The current literature still gives a little information about the relationships between the ABO blood group system and the immune response to the virus or the different disease outcomes. Hypothesizing the presence of a predisposition by some blood groups to COVID-19, we searched for differences between patients towards the different outcomes of disease.We enrolled 330 inpatients with a diagnosis of COVID-19, determining both their ABO blood group system and Rh factor, collecting demographic, clinical and laboratory data. We searched for relationships with COVID-19 outcomes within an observation period of 180 days (Intensification of Care - IoC, Inhospital death, 180-days mortality). The most frequent ABO blood group was A (45.8%); a minor part was represented by group O (38.8%), B (11.5%), AB (3.9%). As for the Rh factor, 86.7% of patients were Rh-positive. There were no significant differences between blood groups and Rh factors as for age, length of hospital stays (LoS), or Charlson Comorbidity Index (CCI), nor we found significant relationships between the ABO groups and COVID-19 outcomes. A significant relation was found between AB group and IoC (p=0.03) while as for the Rh factor, the patients with Rh factor positive died with less frequency during the stay (p=0.03). Cox regression analyses showed substantial differences in the survival functions concerning the Rh factors. The Rh factor seems to be involved in the 180-day prognosis. The survival functions of patients with Rh factor positive show, in fact, significantly better curves when compared to those with Rh factor negative. |
| first_indexed | 2024-04-10T18:35:48Z |
| format | Article |
| id | doaj.art-d3185f08c48f45fcb5c960b2c9eb4a69 |
| institution | Directory Open Access Journal |
| issn | 2038-8322 2038-8330 |
| language | English |
| last_indexed | 2024-04-10T18:35:48Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj.art-d3185f08c48f45fcb5c960b2c9eb4a692023-02-02T01:43:11ZengMDPI AGHematology Reports2038-83222038-83302021-09-0113310.4081/hr.2021.9177COVID-19 and blood groups: A six-months observational study in Ferrara, ItalySalvatore Greco0Nicolò Fabbri1Alessandro Bella2Beatrice Bonsi3Alessandra Violi4Valeria Fortunato5Maurizio Govoni6Giuseppe Graldi7Angelina Passaro8Department of Translational Medicine, University of FerraraDepartment of General Surgery, Ospedale del Delta, LagosantoDepartment of Translational Medicine, University of FerraraDepartment of Translational Medicine, University of FerraraDepartment of Translational Medicine, University of FerraraDepartment of Translational Medicine, University of FerraraBlood Transfusion Service, University Hospital of Ferrara Arcispedale Sant’Anna, ConaUniversity Hospital of FerraraDepartment of Translational Medicine, University of Ferrara; Medical Department, Unit of Internal Medicine, University Hospital of Ferrara Arcispedale Sant’Anna, ConaThe current literature still gives a little information about the relationships between the ABO blood group system and the immune response to the virus or the different disease outcomes. Hypothesizing the presence of a predisposition by some blood groups to COVID-19, we searched for differences between patients towards the different outcomes of disease.We enrolled 330 inpatients with a diagnosis of COVID-19, determining both their ABO blood group system and Rh factor, collecting demographic, clinical and laboratory data. We searched for relationships with COVID-19 outcomes within an observation period of 180 days (Intensification of Care - IoC, Inhospital death, 180-days mortality). The most frequent ABO blood group was A (45.8%); a minor part was represented by group O (38.8%), B (11.5%), AB (3.9%). As for the Rh factor, 86.7% of patients were Rh-positive. There were no significant differences between blood groups and Rh factors as for age, length of hospital stays (LoS), or Charlson Comorbidity Index (CCI), nor we found significant relationships between the ABO groups and COVID-19 outcomes. A significant relation was found between AB group and IoC (p=0.03) while as for the Rh factor, the patients with Rh factor positive died with less frequency during the stay (p=0.03). Cox regression analyses showed substantial differences in the survival functions concerning the Rh factors. The Rh factor seems to be involved in the 180-day prognosis. The survival functions of patients with Rh factor positive show, in fact, significantly better curves when compared to those with Rh factor negative.https://www.pagepress.org/journals/index.php/hr/article/view/9177CoronavirusCOVID-19Rh factorBlood groups |
| spellingShingle | Salvatore Greco Nicolò Fabbri Alessandro Bella Beatrice Bonsi Alessandra Violi Valeria Fortunato Maurizio Govoni Giuseppe Graldi Angelina Passaro COVID-19 and blood groups: A six-months observational study in Ferrara, Italy Hematology Reports Coronavirus COVID-19 Rh factor Blood groups |
| title | COVID-19 and blood groups: A six-months observational study in Ferrara, Italy |
| title_full | COVID-19 and blood groups: A six-months observational study in Ferrara, Italy |
| title_fullStr | COVID-19 and blood groups: A six-months observational study in Ferrara, Italy |
| title_full_unstemmed | COVID-19 and blood groups: A six-months observational study in Ferrara, Italy |
| title_short | COVID-19 and blood groups: A six-months observational study in Ferrara, Italy |
| title_sort | covid 19 and blood groups a six months observational study in ferrara italy |
| topic | Coronavirus COVID-19 Rh factor Blood groups |
| url | https://www.pagepress.org/journals/index.php/hr/article/view/9177 |
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