Influence of Resveratrol on the Cardiovascular Health Effects of Chronic Kidney Disease
Cardiovascular disease (CVD) is closely related to chronic kidney disease (CKD), and patients with CKD have a high risk of CVD-related mortality. Traditional CVD risk factors cannot account for the higher cardiovascular risk of patients with CKD, and standard CVD interventions cannot reduce the mort...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/17/6294 |
| _version_ | 1797555078391922688 |
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| author | Jenn-Yeu Song Ta-Chung Shen Yi-Chou Hou Jia-Feng Chang Chien-Lin Lu Wen-Chih Liu Po-Jui Chen Bo-Hau Chen Cai-Mei Zheng Kuo-Cheng Lu |
| author_facet | Jenn-Yeu Song Ta-Chung Shen Yi-Chou Hou Jia-Feng Chang Chien-Lin Lu Wen-Chih Liu Po-Jui Chen Bo-Hau Chen Cai-Mei Zheng Kuo-Cheng Lu |
| author_sort | Jenn-Yeu Song |
| collection | DOAJ |
| description | Cardiovascular disease (CVD) is closely related to chronic kidney disease (CKD), and patients with CKD have a high risk of CVD-related mortality. Traditional CVD risk factors cannot account for the higher cardiovascular risk of patients with CKD, and standard CVD interventions cannot reduce the mortality rates among patients with CKD. Nontraditional factors related to mineral and vitamin-D metabolic disorders provide some explanation for the increased CVD risk. Non-dialyzable toxins, indoxyl sulfate (IS) and <i>p</i>-cresol sulfate (PCS)—produced in the liver by colonic microorganisms—cause kidney and vascular dysfunction. Plasma trimethylamine-N-oxide (TMAO)—a gut microbe-dependent metabolite of dietary L-carnitine and choline—is elevated in CKD and related to vascular disease, resulting in poorer long-term survival. Therefore, the modulation of colonic flora can improve prospects for patients with CKD. Managing metabolic syndrome, anemia, and abnormal mineral metabolism is recommended for the prevention of CVD in patients with CKD. Considering nontraditional risk factors, the use of resveratrol (RSV), a nutraceutical, can be helpful for patients with CVD and CKD. This paper discusses the beneficial effects of RSV on biologic, pathophysiological and clinical responses, including improvements in intestinal epithelial integrity, modulation of the intestinal microbiota and reduction in hepatic synthesis of IS, PCS and TMAO in patients with CVD and CKD. |
| first_indexed | 2024-03-10T16:42:21Z |
| format | Article |
| id | doaj.art-d319405fd67e4c76bd917d3b1aef1e7d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:42:21Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d319405fd67e4c76bd917d3b1aef1e7d2023-11-20T11:58:03ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-08-012117629410.3390/ijms21176294Influence of Resveratrol on the Cardiovascular Health Effects of Chronic Kidney DiseaseJenn-Yeu Song0Ta-Chung Shen1Yi-Chou Hou2Jia-Feng Chang3Chien-Lin Lu4Wen-Chih Liu5Po-Jui Chen6Bo-Hau Chen7Cai-Mei Zheng8Kuo-Cheng Lu9Division of Cardiovascular Surgery, Department of Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, TaiwanDivision of Cardiovascular Surgery, Department of Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, TaiwanDivision of Nephrology, Department of Medicine, Cardinal-Tien Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City 234, TaiwanDivision of Nephrology, Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, TaiwanDivision of Nephrology, Department of Medicine, Fu Jen Catholic University Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City 242, TaiwanDivision of Nephrology, Department of Medicine, Taipei Hospital, Ministry of Health and Welfare, New Taipei City 242, TaiwanDepartment of Pediatrics, Taoyuan Armed Forces General Hospital, Taoyuan City 325, TaiwanDepartment of Pediatrics, Taoyuan Armed Forces General Hospital, Taoyuan City 325, TaiwanTaipei Medical University-Research Center of Urology and Kidney, Taipei Medical University, Taipei 110, TaiwanDivision of Nephrology, Department of Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, TaiwanCardiovascular disease (CVD) is closely related to chronic kidney disease (CKD), and patients with CKD have a high risk of CVD-related mortality. Traditional CVD risk factors cannot account for the higher cardiovascular risk of patients with CKD, and standard CVD interventions cannot reduce the mortality rates among patients with CKD. Nontraditional factors related to mineral and vitamin-D metabolic disorders provide some explanation for the increased CVD risk. Non-dialyzable toxins, indoxyl sulfate (IS) and <i>p</i>-cresol sulfate (PCS)—produced in the liver by colonic microorganisms—cause kidney and vascular dysfunction. Plasma trimethylamine-N-oxide (TMAO)—a gut microbe-dependent metabolite of dietary L-carnitine and choline—is elevated in CKD and related to vascular disease, resulting in poorer long-term survival. Therefore, the modulation of colonic flora can improve prospects for patients with CKD. Managing metabolic syndrome, anemia, and abnormal mineral metabolism is recommended for the prevention of CVD in patients with CKD. Considering nontraditional risk factors, the use of resveratrol (RSV), a nutraceutical, can be helpful for patients with CVD and CKD. This paper discusses the beneficial effects of RSV on biologic, pathophysiological and clinical responses, including improvements in intestinal epithelial integrity, modulation of the intestinal microbiota and reduction in hepatic synthesis of IS, PCS and TMAO in patients with CVD and CKD.https://www.mdpi.com/1422-0067/21/17/6294cardiovascular diseasechronic kidney diseaseindoxyl sulfatemicrobiota<i>p</i>-cresol sulfateresveratrol |
| spellingShingle | Jenn-Yeu Song Ta-Chung Shen Yi-Chou Hou Jia-Feng Chang Chien-Lin Lu Wen-Chih Liu Po-Jui Chen Bo-Hau Chen Cai-Mei Zheng Kuo-Cheng Lu Influence of Resveratrol on the Cardiovascular Health Effects of Chronic Kidney Disease International Journal of Molecular Sciences cardiovascular disease chronic kidney disease indoxyl sulfate microbiota <i>p</i>-cresol sulfate resveratrol |
| title | Influence of Resveratrol on the Cardiovascular Health Effects of Chronic Kidney Disease |
| title_full | Influence of Resveratrol on the Cardiovascular Health Effects of Chronic Kidney Disease |
| title_fullStr | Influence of Resveratrol on the Cardiovascular Health Effects of Chronic Kidney Disease |
| title_full_unstemmed | Influence of Resveratrol on the Cardiovascular Health Effects of Chronic Kidney Disease |
| title_short | Influence of Resveratrol on the Cardiovascular Health Effects of Chronic Kidney Disease |
| title_sort | influence of resveratrol on the cardiovascular health effects of chronic kidney disease |
| topic | cardiovascular disease chronic kidney disease indoxyl sulfate microbiota <i>p</i>-cresol sulfate resveratrol |
| url | https://www.mdpi.com/1422-0067/21/17/6294 |
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