Developing Anti-<i>Babesia bovis</i> Blood Stage Vaccines: A New Perspective Regarding Synthetic Vaccines
Bovine babesiosis is caused by the Apicomplexa parasites from the genus <i>Babesia</i>. It is one of the most important tick-borne veterinary diseases worldwide; <i>Babesia bovis</i> being the species associated with the most severe clinical signs of the disease and causing t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/6/5219 |
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| author | Laura Cuy-Chaparro César Reyes Eliana Vanessa Díaz-Guiot Darwin Andrés Moreno-Pérez Manuel Alfonso Patarroyo |
| author_facet | Laura Cuy-Chaparro César Reyes Eliana Vanessa Díaz-Guiot Darwin Andrés Moreno-Pérez Manuel Alfonso Patarroyo |
| author_sort | Laura Cuy-Chaparro |
| collection | DOAJ |
| description | Bovine babesiosis is caused by the Apicomplexa parasites from the genus <i>Babesia</i>. It is one of the most important tick-borne veterinary diseases worldwide; <i>Babesia bovis</i> being the species associated with the most severe clinical signs of the disease and causing the greatest economic losses. Many limitations related to chemoprophylaxis and the acaricides control of transmitting vectors have led to the adoption of live attenuated vaccine immunisation against <i>B. bovis</i> as an alternative control strategy. However, whilst this strategy has been effective, several drawbacks related to its production have prompted research into alternative methodologies for producing vaccines. Classical approaches for developing anti-<i>B. bovis</i> vaccines are thus discussed in this review and are compared to a recent functional approach to highlight the latter’s advantages when designing an effective synthetic vaccine targeting this parasite. |
| first_indexed | 2024-03-11T06:27:30Z |
| format | Article |
| id | doaj.art-d319960aedcc4f57997981a62499fd67 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T06:27:30Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d319960aedcc4f57997981a62499fd672023-11-17T11:30:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01246521910.3390/ijms24065219Developing Anti-<i>Babesia bovis</i> Blood Stage Vaccines: A New Perspective Regarding Synthetic VaccinesLaura Cuy-Chaparro0César Reyes1Eliana Vanessa Díaz-Guiot2Darwin Andrés Moreno-Pérez3Manuel Alfonso Patarroyo4PhD Programme in Biotechnology, Sciences Faculty, Universidad Nacional de Colombia, Carrera 45#26-85, Bogotá DC 111321, ColombiaPhD Programme in Biotechnology, Sciences Faculty, Universidad Nacional de Colombia, Carrera 45#26-85, Bogotá DC 111321, ColombiaAnimal Science Faculty, Universidad de Ciencias Aplicadas y Ambientales (U.D.C.A), Calle 222#55-37, Bogotá DC 111166, ColombiaAnimal Science Faculty, Universidad de Ciencias Aplicadas y Ambientales (U.D.C.A), Calle 222#55-37, Bogotá DC 111166, ColombiaMolecular Biology and Immunology Department, Fundación Instituto de Inmunología de Colombia (FIDIC), Carrera 50#26-20, Bogotá DC 111321, ColombiaBovine babesiosis is caused by the Apicomplexa parasites from the genus <i>Babesia</i>. It is one of the most important tick-borne veterinary diseases worldwide; <i>Babesia bovis</i> being the species associated with the most severe clinical signs of the disease and causing the greatest economic losses. Many limitations related to chemoprophylaxis and the acaricides control of transmitting vectors have led to the adoption of live attenuated vaccine immunisation against <i>B. bovis</i> as an alternative control strategy. However, whilst this strategy has been effective, several drawbacks related to its production have prompted research into alternative methodologies for producing vaccines. Classical approaches for developing anti-<i>B. bovis</i> vaccines are thus discussed in this review and are compared to a recent functional approach to highlight the latter’s advantages when designing an effective synthetic vaccine targeting this parasite.https://www.mdpi.com/1422-0067/24/6/5219babesiosis<i>Babesia bovis</i>control strategyvaccinesynthetic vaccine |
| spellingShingle | Laura Cuy-Chaparro César Reyes Eliana Vanessa Díaz-Guiot Darwin Andrés Moreno-Pérez Manuel Alfonso Patarroyo Developing Anti-<i>Babesia bovis</i> Blood Stage Vaccines: A New Perspective Regarding Synthetic Vaccines International Journal of Molecular Sciences babesiosis <i>Babesia bovis</i> control strategy vaccine synthetic vaccine |
| title | Developing Anti-<i>Babesia bovis</i> Blood Stage Vaccines: A New Perspective Regarding Synthetic Vaccines |
| title_full | Developing Anti-<i>Babesia bovis</i> Blood Stage Vaccines: A New Perspective Regarding Synthetic Vaccines |
| title_fullStr | Developing Anti-<i>Babesia bovis</i> Blood Stage Vaccines: A New Perspective Regarding Synthetic Vaccines |
| title_full_unstemmed | Developing Anti-<i>Babesia bovis</i> Blood Stage Vaccines: A New Perspective Regarding Synthetic Vaccines |
| title_short | Developing Anti-<i>Babesia bovis</i> Blood Stage Vaccines: A New Perspective Regarding Synthetic Vaccines |
| title_sort | developing anti i babesia bovis i blood stage vaccines a new perspective regarding synthetic vaccines |
| topic | babesiosis <i>Babesia bovis</i> control strategy vaccine synthetic vaccine |
| url | https://www.mdpi.com/1422-0067/24/6/5219 |
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