Optimal futility stopping boundaries for binary endpoints

Optimal futility stopping boundaries for binary endpoints

Abstract Background Group sequential designs incorporating the option to stop for futility at the time point of an interim analysis can save time and resources. Thereby, the choice of the futility boundary importantly impacts the design’s resulting performance characteristics, including the power an...

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Bibliographic Details
Main Authors: Michaela Maria Freitag, Xieran Li, Geraldine Rauch
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Medical Research Methodology
Subjects:
Single-arm phase II trial
Futility stop
Group sequential design
Binary endpoint
Online Access:https://doi.org/10.1186/s12874-024-02190-w

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