Underlying Mechanisms of Memory Deficits Induced by Etomidate Anesthesia in Aged Rat Model: Critical Role of Immediate Early Genes

Underlying Mechanisms of Memory Deficits Induced by Etomidate Anesthesia in Aged Rat Model: Critical Role of Immediate Early Genes

Background: Etomidate (R-1-[1-ethylphenyl] imidazole-5-ethyl ester) is a widely used anesthetic drug that had been reported to contribute to cognitive deficits after general surgery. However, its underlying mechanisms have not been fully elucidated. In this study, we aimed to explore the neurobiolog...

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Bibliographic Details
Main Authors: Xu Li, Fen Lu, Wei Li, Jun Xu, Xiao-Jing Sun, Ling-Zhi Qin, Qian-Lin Zhang, Yong Yao, Qing-Kai Yu, Xin-Liang Liang
Format: Article
Language:English
Published: Wolters Kluwer 2016-01-01
Series:Chinese Medical Journal
Subjects:
Anesthesia; Cyclic Adenosine 3′
5′- Monophosphate Response Element-binding Phosphorylation; Etomidate; Immediate Early Genes; Neuronal Death; Oxidative Stress
Online Access:http://www.cmj.org/article.asp?issn=0366-6999;year=2016;volume=129;issue=1;spage=48;epage=53;aulast=Li

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