HIV Neuroinflammation: The Role of Exosomes in Cell Signaling, Prognostic and Diagnostic Biomarkers and Drug Delivery

HIV Neuroinflammation: The Role of Exosomes in Cell Signaling, Prognostic and Diagnostic Biomarkers and Drug Delivery

Fifty to sixty percent of HIV-1 positive patients experience HIV-1 associated neurocognitive disorders (HAND) likely due to persistent inflammation and blood–brain barrier (BBB) dysfunction. The role that microglia and astrocytes play in HAND pathogenesis has been well delineated; however, the role...

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Bibliographic Details
Main Authors: Supriya D. Mahajan, Nigel Smith Ordain, Hilliard Kutscher, Shanta Karki, Jessica L. Reynolds
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
HIV neuroinflammation
exosomes
signaling
delivery
blood-brain barrier
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.637192/full

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