A SoxB gene acts as an anterior gap gene and regulates posterior segment addition in a spider
Sox genes encode a set of highly conserved transcription factors that regulate many developmental processes. In insects, the SoxB gene Dichaete is the only Sox gene known to be involved in segmentation. To determine if similar mechanisms are used in other arthropods, we investigated the role of Sox...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-08-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/37567 |
| _version_ | 1811181121925283840 |
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| author | Christian Louis Bonatto Paese Anna Schoenauer Daniel J Leite Steven Russell Alistair P McGregor |
| author_facet | Christian Louis Bonatto Paese Anna Schoenauer Daniel J Leite Steven Russell Alistair P McGregor |
| author_sort | Christian Louis Bonatto Paese |
| collection | DOAJ |
| description | Sox genes encode a set of highly conserved transcription factors that regulate many developmental processes. In insects, the SoxB gene Dichaete is the only Sox gene known to be involved in segmentation. To determine if similar mechanisms are used in other arthropods, we investigated the role of Sox genes during segmentation in the spider Parasteatoda tepidariorum. While Dichaete does not appear to be involved in spider segmentation, we found that the closely related Sox21b-1 gene acts as a gap gene during formation of anterior segments and is also part of the segmentation clock for development of the segment addition zone and sequential addition of opisthosomal segments. Thus, we have found that two different mechanisms of segmentation in a non-mandibulate arthropod are regulated by a SoxB gene. Our work provides new insights into the function of an important and conserved gene family, and the evolution of the regulation of segmentation in arthropods. |
| first_indexed | 2024-04-11T09:14:19Z |
| format | Article |
| id | doaj.art-d31c4921131144b29630418407cb82d3 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:14:19Z |
| publishDate | 2018-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-d31c4921131144b29630418407cb82d32022-12-22T04:32:25ZengeLife Sciences Publications LtdeLife2050-084X2018-08-01710.7554/eLife.37567A SoxB gene acts as an anterior gap gene and regulates posterior segment addition in a spiderChristian Louis Bonatto Paese0https://orcid.org/0000-0001-5992-5209Anna Schoenauer1Daniel J Leite2Steven Russell3https://orcid.org/0000-0003-0546-3031Alistair P McGregor4https://orcid.org/0000-0002-2908-2420Laboratory of Evolutionary Developmental Biology, Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, United KingdomLaboratory of Evolutionary Developmental Biology, Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, United KingdomLaboratory of Evolutionary Developmental Biology, Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, United KingdomDepartment of Genetics, University of Cambridge, Cambridge, United KingdomLaboratory of Evolutionary Developmental Biology, Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, United KingdomSox genes encode a set of highly conserved transcription factors that regulate many developmental processes. In insects, the SoxB gene Dichaete is the only Sox gene known to be involved in segmentation. To determine if similar mechanisms are used in other arthropods, we investigated the role of Sox genes during segmentation in the spider Parasteatoda tepidariorum. While Dichaete does not appear to be involved in spider segmentation, we found that the closely related Sox21b-1 gene acts as a gap gene during formation of anterior segments and is also part of the segmentation clock for development of the segment addition zone and sequential addition of opisthosomal segments. Thus, we have found that two different mechanisms of segmentation in a non-mandibulate arthropod are regulated by a SoxB gene. Our work provides new insights into the function of an important and conserved gene family, and the evolution of the regulation of segmentation in arthropods.https://elifesciences.org/articles/37567parasteatoda tepidariorumspiderevolutiondevelopmentsegmentation |
| spellingShingle | Christian Louis Bonatto Paese Anna Schoenauer Daniel J Leite Steven Russell Alistair P McGregor A SoxB gene acts as an anterior gap gene and regulates posterior segment addition in a spider eLife parasteatoda tepidariorum spider evolution development segmentation |
| title | A SoxB gene acts as an anterior gap gene and regulates posterior segment addition in a spider |
| title_full | A SoxB gene acts as an anterior gap gene and regulates posterior segment addition in a spider |
| title_fullStr | A SoxB gene acts as an anterior gap gene and regulates posterior segment addition in a spider |
| title_full_unstemmed | A SoxB gene acts as an anterior gap gene and regulates posterior segment addition in a spider |
| title_short | A SoxB gene acts as an anterior gap gene and regulates posterior segment addition in a spider |
| title_sort | soxb gene acts as an anterior gap gene and regulates posterior segment addition in a spider |
| topic | parasteatoda tepidariorum spider evolution development segmentation |
| url | https://elifesciences.org/articles/37567 |
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