p53/E2F7 axis promotes temozolomide chemoresistance in glioblastoma multiforme

p53/E2F7 axis promotes temozolomide chemoresistance in glioblastoma multiforme

Abstract Background Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer, and chemoresistance poses a significant challenge to the survival and prognosis of GBM. Although numerous regulatory mechanisms that contribute to chemoresistance have been identified, many questions remai...

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Bibliographic Details
Main Authors: Jiao Meng, Wei Qian, Zhenkun Yang, Lingli Gong, Daxing Xu, Hongbo Huang, Xinyi Jiang, Zhening Pu, Ying Yin, Jian Zou
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Cancer
Subjects:
E2F7
p53
Chemoresistance
Temozolomide
Glioblastoma multiforme
Online Access:https://doi.org/10.1186/s12885-024-12017-y

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