Influence of the HDAC Inhibitor Valproic Acid on the Growth and Proliferation of Temsirolimus-Resistant Prostate Cancer Cells In Vitro

Influence of the HDAC Inhibitor Valproic Acid on the Growth and Proliferation of Temsirolimus-Resistant Prostate Cancer Cells In Vitro

The mechanistic target of rapamycin (mTOR) is elevated in prostate cancer, making this protein attractive for tumor treatment. Unfortunately, resistance towards mTOR inhibitors develops and the tumor becomes reactivated. We determined whether epigenetic modulation by the histone deacetylase (HDAC) i...

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Bibliographic Details
Main Authors: Jasmina Makarević, Jochen Rutz, Eva Juengel, Sebastian Maxeiner, Igor Tsaur, Felix K.-H. Chun, Jürgen Bereiter-Hahn, Roman A. Blaheta
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
mtor
HDAC
cell growth
cdk
cyclins
prostate cancer
resistance
valproic acid
temsirolimus
Online Access:https://www.mdpi.com/2072-6694/11/4/566

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