New non-invasive indexes of arterial stiffness are significantly correlated with severity and complexity of coronary atherosclerosis
Background: Endothelial dysfunction and increased arterial stiffness gradually develop before the manifestation of catastrophic cardiovascular events. Therefore, detection and assessment of vascular function are required to address pre-existing pathological conditions. However, the currently availab...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-02-01
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| Series: | Clinical and Experimental Hypertension |
| Online Access: | http://dx.doi.org/10.1080/10641963.2018.1465072 |
| _version_ | 1797681399902240768 |
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| author | Hiroshi Doi Tomoaki Ishigami Rie Nakashima-Sasaki Tabito Kino Lin Chen Kentaro Arakawa Sae Teranaka Shintaro Minegishi Kaito Abe Toshiyuki Ishikawa Teruyasu Sugano Kouichi Tamura |
| author_facet | Hiroshi Doi Tomoaki Ishigami Rie Nakashima-Sasaki Tabito Kino Lin Chen Kentaro Arakawa Sae Teranaka Shintaro Minegishi Kaito Abe Toshiyuki Ishikawa Teruyasu Sugano Kouichi Tamura |
| author_sort | Hiroshi Doi |
| collection | DOAJ |
| description | Background: Endothelial dysfunction and increased arterial stiffness gradually develop before the manifestation of catastrophic cardiovascular events. Therefore, detection and assessment of vascular function are required to address pre-existing pathological conditions. However, the currently available diagnostic devices and methods are insufficient due to variability among investigators and the time-consuming nature of manual procedures. Methods: Recently, novel devices were developed for the detection of both arterial stiffness and endothelial dysfunction in a single blood pressure measurement using a cuff-oscillometric technique (AVE-1500, Shisei Datum, Japan). API (arterial pressure volume index) is defined as the reciprocal of the slope of the tangent of the brachial artery pressure-volume curve, and AVI (arterial velocity pulse index) is defined as the ratio of the difference between the ejection and reflection waves. In the present study, we performed retrospective, cross-sectional analyses of subjects (n = 102; mean age = 70.5 ± 10.4 years) with detailed coronary angiographic examinations and clinical background parameters. Results: After adjusting for various variables using multiple linear regression analyses, we found that API, but not AVI, was significantly correlated with coronary artery severity and complexity scores. Conclusions: We propose that API may be a new vascular index useful for monitoring and assessing the severity and complexity of atherosclerosis in subjects with coronary artery disease and for evaluating atherosclerotic diseases. |
| first_indexed | 2024-03-11T23:44:23Z |
| format | Article |
| id | doaj.art-d31fa1384572404c87e17cec2953962d |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:44:23Z |
| publishDate | 2019-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-d31fa1384572404c87e17cec2953962d2023-09-19T15:19:27ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062019-02-0141218719310.1080/10641963.2018.14650721465072New non-invasive indexes of arterial stiffness are significantly correlated with severity and complexity of coronary atherosclerosisHiroshi Doi0Tomoaki Ishigami1Rie Nakashima-Sasaki2Tabito Kino3Lin Chen4Kentaro Arakawa5Sae Teranaka6Shintaro Minegishi7Kaito Abe8Toshiyuki Ishikawa9Teruyasu Sugano10Kouichi Tamura11Yokohama City University Graduate School of MedicineYokohama City University Graduate School of MedicineYokohama City University Graduate School of MedicineYokohama City University Graduate School of MedicineYokohama City University Graduate School of MedicineYokohama City University Graduate School of MedicineYokohama City University Graduate School of MedicineYokohama City University Graduate School of MedicineYokohama City University Graduate School of MedicineYokohama City University Graduate School of MedicineYokohama City University Graduate School of MedicineYokohama City University Graduate School of MedicineBackground: Endothelial dysfunction and increased arterial stiffness gradually develop before the manifestation of catastrophic cardiovascular events. Therefore, detection and assessment of vascular function are required to address pre-existing pathological conditions. However, the currently available diagnostic devices and methods are insufficient due to variability among investigators and the time-consuming nature of manual procedures. Methods: Recently, novel devices were developed for the detection of both arterial stiffness and endothelial dysfunction in a single blood pressure measurement using a cuff-oscillometric technique (AVE-1500, Shisei Datum, Japan). API (arterial pressure volume index) is defined as the reciprocal of the slope of the tangent of the brachial artery pressure-volume curve, and AVI (arterial velocity pulse index) is defined as the ratio of the difference between the ejection and reflection waves. In the present study, we performed retrospective, cross-sectional analyses of subjects (n = 102; mean age = 70.5 ± 10.4 years) with detailed coronary angiographic examinations and clinical background parameters. Results: After adjusting for various variables using multiple linear regression analyses, we found that API, but not AVI, was significantly correlated with coronary artery severity and complexity scores. Conclusions: We propose that API may be a new vascular index useful for monitoring and assessing the severity and complexity of atherosclerosis in subjects with coronary artery disease and for evaluating atherosclerotic diseases.http://dx.doi.org/10.1080/10641963.2018.1465072 |
| spellingShingle | Hiroshi Doi Tomoaki Ishigami Rie Nakashima-Sasaki Tabito Kino Lin Chen Kentaro Arakawa Sae Teranaka Shintaro Minegishi Kaito Abe Toshiyuki Ishikawa Teruyasu Sugano Kouichi Tamura New non-invasive indexes of arterial stiffness are significantly correlated with severity and complexity of coronary atherosclerosis Clinical and Experimental Hypertension |
| title | New non-invasive indexes of arterial stiffness are significantly correlated with severity and complexity of coronary atherosclerosis |
| title_full | New non-invasive indexes of arterial stiffness are significantly correlated with severity and complexity of coronary atherosclerosis |
| title_fullStr | New non-invasive indexes of arterial stiffness are significantly correlated with severity and complexity of coronary atherosclerosis |
| title_full_unstemmed | New non-invasive indexes of arterial stiffness are significantly correlated with severity and complexity of coronary atherosclerosis |
| title_short | New non-invasive indexes of arterial stiffness are significantly correlated with severity and complexity of coronary atherosclerosis |
| title_sort | new non invasive indexes of arterial stiffness are significantly correlated with severity and complexity of coronary atherosclerosis |
| url | http://dx.doi.org/10.1080/10641963.2018.1465072 |
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