Unraveling Molecular and Genetic Insights into Neurodegenerative Diseases: Advances in Understanding Alzheimer’s, Parkinson’s, and Huntington’s Diseases and Amyotrophic Lateral Sclerosis
Neurodegenerative diseases are, according to recent studies, one of the main causes of disability and death worldwide. Interest in molecular genetics has started to experience exponential growth thanks to numerous advancements in technology, shifts in the understanding of the disease as a phenomenon...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/13/10809 |
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| author | Alexandru Vlad Ciurea Aurel George Mohan Razvan-Adrian Covache-Busuioc Horia-Petre Costin Luca-Andrei Glavan Antonio-Daniel Corlatescu Vicentiu Mircea Saceleanu |
| author_facet | Alexandru Vlad Ciurea Aurel George Mohan Razvan-Adrian Covache-Busuioc Horia-Petre Costin Luca-Andrei Glavan Antonio-Daniel Corlatescu Vicentiu Mircea Saceleanu |
| author_sort | Alexandru Vlad Ciurea |
| collection | DOAJ |
| description | Neurodegenerative diseases are, according to recent studies, one of the main causes of disability and death worldwide. Interest in molecular genetics has started to experience exponential growth thanks to numerous advancements in technology, shifts in the understanding of the disease as a phenomenon, and the change in the perspective regarding gene editing and the advantages of this action. The aim of this paper is to analyze the newest approaches in genetics and molecular sciences regarding four of the most important neurodegenerative disorders: Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. We intend through this review to focus on the newest treatment, diagnosis, and predictions regarding this large group of diseases, in order to obtain a more accurate analysis and to identify the emerging signs that could lead to a better outcome in order to increase both the quality and the life span of the patient. Moreover, this review could provide evidence of future possible novel therapies that target the specific genes and that could be useful to be taken into consideration when the classical approaches fail to shed light. |
| first_indexed | 2024-03-11T01:39:27Z |
| format | Article |
| id | doaj.art-d31fe7486f58490d86c2f752815fc8c8 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T01:39:27Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d31fe7486f58490d86c2f752815fc8c82023-11-18T16:43:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124131080910.3390/ijms241310809Unraveling Molecular and Genetic Insights into Neurodegenerative Diseases: Advances in Understanding Alzheimer’s, Parkinson’s, and Huntington’s Diseases and Amyotrophic Lateral SclerosisAlexandru Vlad Ciurea0Aurel George Mohan1Razvan-Adrian Covache-Busuioc2Horia-Petre Costin3Luca-Andrei Glavan4Antonio-Daniel Corlatescu5Vicentiu Mircea Saceleanu6Department of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, Bihor County Emergency Clinical Hospital, 410167 Oradea, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaNeurosurgery Department, Sibiu County Emergency Hospital, 550245 Sibiu, RomaniaNeurodegenerative diseases are, according to recent studies, one of the main causes of disability and death worldwide. Interest in molecular genetics has started to experience exponential growth thanks to numerous advancements in technology, shifts in the understanding of the disease as a phenomenon, and the change in the perspective regarding gene editing and the advantages of this action. The aim of this paper is to analyze the newest approaches in genetics and molecular sciences regarding four of the most important neurodegenerative disorders: Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. We intend through this review to focus on the newest treatment, diagnosis, and predictions regarding this large group of diseases, in order to obtain a more accurate analysis and to identify the emerging signs that could lead to a better outcome in order to increase both the quality and the life span of the patient. Moreover, this review could provide evidence of future possible novel therapies that target the specific genes and that could be useful to be taken into consideration when the classical approaches fail to shed light.https://www.mdpi.com/1422-0067/24/13/10809molecular geneticsneurodegenerative diseasemolecular pathologyepigeneticsgene expressiontherapeutic targets |
| spellingShingle | Alexandru Vlad Ciurea Aurel George Mohan Razvan-Adrian Covache-Busuioc Horia-Petre Costin Luca-Andrei Glavan Antonio-Daniel Corlatescu Vicentiu Mircea Saceleanu Unraveling Molecular and Genetic Insights into Neurodegenerative Diseases: Advances in Understanding Alzheimer’s, Parkinson’s, and Huntington’s Diseases and Amyotrophic Lateral Sclerosis International Journal of Molecular Sciences molecular genetics neurodegenerative disease molecular pathology epigenetics gene expression therapeutic targets |
| title | Unraveling Molecular and Genetic Insights into Neurodegenerative Diseases: Advances in Understanding Alzheimer’s, Parkinson’s, and Huntington’s Diseases and Amyotrophic Lateral Sclerosis |
| title_full | Unraveling Molecular and Genetic Insights into Neurodegenerative Diseases: Advances in Understanding Alzheimer’s, Parkinson’s, and Huntington’s Diseases and Amyotrophic Lateral Sclerosis |
| title_fullStr | Unraveling Molecular and Genetic Insights into Neurodegenerative Diseases: Advances in Understanding Alzheimer’s, Parkinson’s, and Huntington’s Diseases and Amyotrophic Lateral Sclerosis |
| title_full_unstemmed | Unraveling Molecular and Genetic Insights into Neurodegenerative Diseases: Advances in Understanding Alzheimer’s, Parkinson’s, and Huntington’s Diseases and Amyotrophic Lateral Sclerosis |
| title_short | Unraveling Molecular and Genetic Insights into Neurodegenerative Diseases: Advances in Understanding Alzheimer’s, Parkinson’s, and Huntington’s Diseases and Amyotrophic Lateral Sclerosis |
| title_sort | unraveling molecular and genetic insights into neurodegenerative diseases advances in understanding alzheimer s parkinson s and huntington s diseases and amyotrophic lateral sclerosis |
| topic | molecular genetics neurodegenerative disease molecular pathology epigenetics gene expression therapeutic targets |
| url | https://www.mdpi.com/1422-0067/24/13/10809 |
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