Racial/Ethnic Disparities in Exposure, Disease Susceptibility, and Clinical Outcomes during COVID-19 Pandemic in National Cohort of Adults, United States

We examined racial/ethnic disparities for COVID-19 seroconversion and hospitalization within a prospective cohort (n = 6,740) in the United States enrolled in March 2020 and followed-up through October 2021. Potential SARS-CoV-2 exposure, susceptibility to COVID-19 complications, and access to heal...

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Main Authors: McKaylee M. Robertson, Meghana G. Shamsunder, Ellen Brazier, Mekhala Mantravadi, Rebecca Zimba, Madhura S. Rane, Drew A. Westmoreland, Angela M. Parcesepe, Andrew R. Maroko, Sarah G. Kulkarni, Christian Grov, Denis Nash
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2022-11-01
Series:Emerging Infectious Diseases
Subjects:
Online Access:https://wwwnc.cdc.gov/eid/article/28/11/22-0072_article
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author McKaylee M. Robertson
Meghana G. Shamsunder
Ellen Brazier
Mekhala Mantravadi
Rebecca Zimba
Madhura S. Rane
Drew A. Westmoreland
Angela M. Parcesepe
Andrew R. Maroko
Sarah G. Kulkarni
Christian Grov
Denis Nash
author_facet McKaylee M. Robertson
Meghana G. Shamsunder
Ellen Brazier
Mekhala Mantravadi
Rebecca Zimba
Madhura S. Rane
Drew A. Westmoreland
Angela M. Parcesepe
Andrew R. Maroko
Sarah G. Kulkarni
Christian Grov
Denis Nash
author_sort McKaylee M. Robertson
collection DOAJ
description We examined racial/ethnic disparities for COVID-19 seroconversion and hospitalization within a prospective cohort (n = 6,740) in the United States enrolled in March 2020 and followed-up through October 2021. Potential SARS-CoV-2 exposure, susceptibility to COVID-19 complications, and access to healthcare varied by race/ethnicity. Hispanic and Black non-Hispanic participants had more exposure risk and difficulty with healthcare access than white participants. Participants with more exposure had greater odds of seroconversion. Participants with more susceptibility and more barriers to healthcare had greater odds of hospitalization. Race/ethnicity positively modified the association between susceptibility and hospitalization. Findings might help to explain the disproportionate burden of SARS-CoV-2 infections and complications among Hispanic/Latino/a and Black non-Hispanic persons. Primary and secondary prevention efforts should address disparities in exposure, vaccination, and treatment for COVID-19.
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spelling doaj.art-d32062b5802a426e8f1de79dde64ec6e2022-12-22T02:36:03ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592022-11-0128112171218010.3201/eid2811.220072Racial/Ethnic Disparities in Exposure, Disease Susceptibility, and Clinical Outcomes during COVID-19 Pandemic in National Cohort of Adults, United StatesMcKaylee M. RobertsonMeghana G. ShamsunderEllen BrazierMekhala MantravadiRebecca ZimbaMadhura S. RaneDrew A. WestmorelandAngela M. ParcesepeAndrew R. MarokoSarah G. KulkarniChristian GrovDenis Nash We examined racial/ethnic disparities for COVID-19 seroconversion and hospitalization within a prospective cohort (n = 6,740) in the United States enrolled in March 2020 and followed-up through October 2021. Potential SARS-CoV-2 exposure, susceptibility to COVID-19 complications, and access to healthcare varied by race/ethnicity. Hispanic and Black non-Hispanic participants had more exposure risk and difficulty with healthcare access than white participants. Participants with more exposure had greater odds of seroconversion. Participants with more susceptibility and more barriers to healthcare had greater odds of hospitalization. Race/ethnicity positively modified the association between susceptibility and hospitalization. Findings might help to explain the disproportionate burden of SARS-CoV-2 infections and complications among Hispanic/Latino/a and Black non-Hispanic persons. Primary and secondary prevention efforts should address disparities in exposure, vaccination, and treatment for COVID-19. https://wwwnc.cdc.gov/eid/article/28/11/22-0072_articleCOVID-19coronavirus diseasesevere acute respiratory syndrome coronavirus 2SARS-CoV-2coronavirusesviruses
spellingShingle McKaylee M. Robertson
Meghana G. Shamsunder
Ellen Brazier
Mekhala Mantravadi
Rebecca Zimba
Madhura S. Rane
Drew A. Westmoreland
Angela M. Parcesepe
Andrew R. Maroko
Sarah G. Kulkarni
Christian Grov
Denis Nash
Racial/Ethnic Disparities in Exposure, Disease Susceptibility, and Clinical Outcomes during COVID-19 Pandemic in National Cohort of Adults, United States
Emerging Infectious Diseases
COVID-19
coronavirus disease
severe acute respiratory syndrome coronavirus 2
SARS-CoV-2
coronaviruses
viruses
title Racial/Ethnic Disparities in Exposure, Disease Susceptibility, and Clinical Outcomes during COVID-19 Pandemic in National Cohort of Adults, United States
title_full Racial/Ethnic Disparities in Exposure, Disease Susceptibility, and Clinical Outcomes during COVID-19 Pandemic in National Cohort of Adults, United States
title_fullStr Racial/Ethnic Disparities in Exposure, Disease Susceptibility, and Clinical Outcomes during COVID-19 Pandemic in National Cohort of Adults, United States
title_full_unstemmed Racial/Ethnic Disparities in Exposure, Disease Susceptibility, and Clinical Outcomes during COVID-19 Pandemic in National Cohort of Adults, United States
title_short Racial/Ethnic Disparities in Exposure, Disease Susceptibility, and Clinical Outcomes during COVID-19 Pandemic in National Cohort of Adults, United States
title_sort racial ethnic disparities in exposure disease susceptibility and clinical outcomes during covid 19 pandemic in national cohort of adults united states
topic COVID-19
coronavirus disease
severe acute respiratory syndrome coronavirus 2
SARS-CoV-2
coronaviruses
viruses
url https://wwwnc.cdc.gov/eid/article/28/11/22-0072_article
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