Selenium as an Essential Micronutrient: Roles in Cell Cycle and Apoptosis
Selenium is an essential trace element for humans and animals, and selenium deficiency is associated with several disease conditions such as immune impairment. In addition, selenium intakes that are greater than the recommended daily allowance (RDA) appear to protect against certain types of cancers...
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| Format: | Article |
| Language: | English |
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MDPI AG
2009-03-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/14/3/1263/ |
| _version_ | 1811279005259661312 |
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| author | Huawei Zeng |
| author_facet | Huawei Zeng |
| author_sort | Huawei Zeng |
| collection | DOAJ |
| description | Selenium is an essential trace element for humans and animals, and selenium deficiency is associated with several disease conditions such as immune impairment. In addition, selenium intakes that are greater than the recommended daily allowance (RDA) appear to protect against certain types of cancers. In humans and animals, cell proliferation and death must be regulated to maintain tissue homeostasis, and it has been well documented that numerous human diseases are directly related to the control of cell cycle progression and apoptosis. Thus, the elucidation of the mechanisms by which selenium regulates the cell cycle and apoptosis can lead to a better understanding of the nature of selenium’s essentiality and its role in disease prevention. This article reviews the status of knowledge concerning the effect of selenium on cell cycle and apoptosis |
| first_indexed | 2024-04-13T00:45:53Z |
| format | Article |
| id | doaj.art-d320977d1ed84e728aefa324d1046484 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T00:45:53Z |
| publishDate | 2009-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d320977d1ed84e728aefa324d10464842022-12-22T03:10:00ZengMDPI AGMolecules1420-30492009-03-011431263127810.3390/molecules14031263Selenium as an Essential Micronutrient: Roles in Cell Cycle and ApoptosisHuawei ZengSelenium is an essential trace element for humans and animals, and selenium deficiency is associated with several disease conditions such as immune impairment. In addition, selenium intakes that are greater than the recommended daily allowance (RDA) appear to protect against certain types of cancers. In humans and animals, cell proliferation and death must be regulated to maintain tissue homeostasis, and it has been well documented that numerous human diseases are directly related to the control of cell cycle progression and apoptosis. Thus, the elucidation of the mechanisms by which selenium regulates the cell cycle and apoptosis can lead to a better understanding of the nature of selenium’s essentiality and its role in disease prevention. This article reviews the status of knowledge concerning the effect of selenium on cell cycle and apoptosishttp://www.mdpi.com/1420-3049/14/3/1263/SeleniumCell proliferationCell cycleApoptosisCancer |
| spellingShingle | Huawei Zeng Selenium as an Essential Micronutrient: Roles in Cell Cycle and Apoptosis Molecules Selenium Cell proliferation Cell cycle Apoptosis Cancer |
| title | Selenium as an Essential Micronutrient: Roles in Cell Cycle and Apoptosis |
| title_full | Selenium as an Essential Micronutrient: Roles in Cell Cycle and Apoptosis |
| title_fullStr | Selenium as an Essential Micronutrient: Roles in Cell Cycle and Apoptosis |
| title_full_unstemmed | Selenium as an Essential Micronutrient: Roles in Cell Cycle and Apoptosis |
| title_short | Selenium as an Essential Micronutrient: Roles in Cell Cycle and Apoptosis |
| title_sort | selenium as an essential micronutrient roles in cell cycle and apoptosis |
| topic | Selenium Cell proliferation Cell cycle Apoptosis Cancer |
| url | http://www.mdpi.com/1420-3049/14/3/1263/ |
| work_keys_str_mv | AT huaweizeng seleniumasanessentialmicronutrientrolesincellcycleandapoptosis |