Naringenin Produces Neuroprotection Against LPS-Induced Dopamine Neurotoxicity via the Inhibition of Microglial NLRP3 Inflammasome Activation

Naringenin Produces Neuroprotection Against LPS-Induced Dopamine Neurotoxicity via the Inhibition of Microglial NLRP3 Inflammasome Activation

Background: Parkinson's disease (PD) is the second most prevalent central nervous system (CNS) degenerative disease and characterized by slow and progressive loss of dopamine (DA) neurons in the midbrain substantia nigra. Microglia-mediated neuroinflammation has been considered as the major cen...

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Bibliographic Details
Main Authors: Ce Chen, Yi-Zheng Wei, Xue-Mei He, Dai-Di Li, Guo-Qing Wang, Jing-Jie Li, Feng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
Parkinson's disease
microglia
inflammasome
naringenin
neuroprotection
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00936/full

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