Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses
The recent emergence of Zika virus (ZIKV) in Brazil was associated with an increased number of fetal brain infections that resulted in a spectrum of congenital neurological complications known as congenital Zika syndrome (CZS). Herein, we generated de novo from sequence data an early Asian lineage Z...
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| Format: | Article |
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MDPI AG
2018-10-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/10/10/541 |
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| author | Yin Xiang Setoh Nias Y. Peng Eri Nakayama Alberto A. Amarilla Natalie A. Prow Andreas Suhrbier Alexander A. Khromykh |
| author_facet | Yin Xiang Setoh Nias Y. Peng Eri Nakayama Alberto A. Amarilla Natalie A. Prow Andreas Suhrbier Alexander A. Khromykh |
| author_sort | Yin Xiang Setoh |
| collection | DOAJ |
| description | The recent emergence of Zika virus (ZIKV) in Brazil was associated with an increased number of fetal brain infections that resulted in a spectrum of congenital neurological complications known as congenital Zika syndrome (CZS). Herein, we generated de novo from sequence data an early Asian lineage ZIKV isolate (ZIKV-MY; Malaysia, 1966) not associated with microcephaly and compared the in vitro replication kinetics and fetal brain infection in interferon α/β receptor 1 knockout (IFNAR1−/−) dams of this isolate and of a Brazilian isolate (ZIKV-Natal; Natal, 2015) unequivocally associated with microcephaly. The replication efficiencies of ZIKV-MY and ZIKV-Natal in A549 and Vero cells were similar, while ZIKV-MY replicated more efficiently in wild-type (WT) and IFNAR−/− mouse embryonic fibroblasts. Viremias in IFNAR1−/− dams were similar after infection with ZIKV-MY or ZIKV-Natal, and importantly, infection of fetal brains was also not significantly different. Thus, fetal brain infection does not appear to be a unique feature of Brazilian ZIKV isolates. |
| first_indexed | 2024-12-22T22:46:59Z |
| format | Article |
| id | doaj.art-d3226f973f4a4d2e823901cf1f3233f2 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-22T22:46:59Z |
| publishDate | 2018-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-d3226f973f4a4d2e823901cf1f3233f22022-12-21T18:10:04ZengMDPI AGViruses1999-49152018-10-01101054110.3390/v10100541v10100541Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika VirusesYin Xiang Setoh0Nias Y. Peng1Eri Nakayama2Alberto A. Amarilla3Natalie A. Prow4Andreas Suhrbier5Alexander A. Khromykh6Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia 4072, AustraliaAustralian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia 4072, AustraliaInflammation Biology Group, QIMR Berghofer Medical Research Institute, Brisbane 4006, AustraliaAustralian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia 4072, AustraliaInflammation Biology Group, QIMR Berghofer Medical Research Institute, Brisbane 4006, AustraliaInflammation Biology Group, QIMR Berghofer Medical Research Institute, Brisbane 4006, AustraliaAustralian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia 4072, AustraliaThe recent emergence of Zika virus (ZIKV) in Brazil was associated with an increased number of fetal brain infections that resulted in a spectrum of congenital neurological complications known as congenital Zika syndrome (CZS). Herein, we generated de novo from sequence data an early Asian lineage ZIKV isolate (ZIKV-MY; Malaysia, 1966) not associated with microcephaly and compared the in vitro replication kinetics and fetal brain infection in interferon α/β receptor 1 knockout (IFNAR1−/−) dams of this isolate and of a Brazilian isolate (ZIKV-Natal; Natal, 2015) unequivocally associated with microcephaly. The replication efficiencies of ZIKV-MY and ZIKV-Natal in A549 and Vero cells were similar, while ZIKV-MY replicated more efficiently in wild-type (WT) and IFNAR−/− mouse embryonic fibroblasts. Viremias in IFNAR1−/− dams were similar after infection with ZIKV-MY or ZIKV-Natal, and importantly, infection of fetal brains was also not significantly different. Thus, fetal brain infection does not appear to be a unique feature of Brazilian ZIKV isolates.http://www.mdpi.com/1999-4915/10/10/541Zika viruspregnancyfetal infectioncongenital Zika syndromeAsian lineage |
| spellingShingle | Yin Xiang Setoh Nias Y. Peng Eri Nakayama Alberto A. Amarilla Natalie A. Prow Andreas Suhrbier Alexander A. Khromykh Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses Viruses Zika virus pregnancy fetal infection congenital Zika syndrome Asian lineage |
| title | Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses |
| title_full | Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses |
| title_fullStr | Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses |
| title_full_unstemmed | Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses |
| title_short | Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses |
| title_sort | fetal brain infection is not a unique characteristic of brazilian zika viruses |
| topic | Zika virus pregnancy fetal infection congenital Zika syndrome Asian lineage |
| url | http://www.mdpi.com/1999-4915/10/10/541 |
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