PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways

PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways

Abstract Background Murine xenografts of pediatric leukemia accurately recapitulate genomic aberrations. How this translates to the functional capacity of cells remains unclear. Here, we studied global protein abundance, phosphorylation, and protein maturation by proteolytic processing in 11 pediatr...

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Bibliographic Details
Main Authors: Anuli C. Uzozie, Enes K. Ergin, Nina Rolf, Janice Tsui, Amanda Lorentzian, Samuel S. H. Weng, Lorenz Nierves, Theodore G. Smith, C. James Lim, Christopher A. Maxwell, Gregor S. D. Reid, Philipp F. Lange
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Leukemia
Xenograft
Proteolysis
Proteome
N termini
Phosphorylation
Online Access:https://doi.org/10.1186/s13046-021-01835-8

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