Primary melanoma of submandibular gland: case report and literature review of a very rare entity
Abstract Background Cutaneous melanomas account for more than 95% of all cases of primary melanoma, making non-cutaneous primary melanomas truly rare. Cases of primary mucosal melanomas of the oral cavity have been widely described; however, instances of primary melanomas arising from salivary gland...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-08-01
|
| Series: | BMC Oral Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12903-022-02380-2 |
| _version_ | 1818084408829149184 |
|---|---|
| author | Hassan Mir Mohammad Sadeghi Ramtin Dastgir Shaghayegh Bozorg Zadeh Fatemeh Mashhadiabbas Abbas Karimi Meysam Mohammadi Khah |
| author_facet | Hassan Mir Mohammad Sadeghi Ramtin Dastgir Shaghayegh Bozorg Zadeh Fatemeh Mashhadiabbas Abbas Karimi Meysam Mohammadi Khah |
| author_sort | Hassan Mir Mohammad Sadeghi |
| collection | DOAJ |
| description | Abstract Background Cutaneous melanomas account for more than 95% of all cases of primary melanoma, making non-cutaneous primary melanomas truly rare. Cases of primary mucosal melanomas of the oral cavity have been widely described; however, instances of primary melanomas arising from salivary glands have been rarely described. To date, this is only the second case of primary melanoma of the submandibular gland. Case presentation This is a report of a case of a 36-year-old healthy male patient, who was referred to us with the chief complaint of a growing swelling on the left side of his lower jaw. Evaluations revealed an evident facial asymmetry in the frontal view with a firm, non-tender swelling. Initial orthopantomogram did not reveal any alterations in the trabeculation or morphology of the jaws and the surrounding structures. A soft tissue ultrasonography of the left submandibular gland and anterior region of mandible revealed a hypoechoic cystic mass with numerous micro-echoes. Further para-clinical examinations yielded the definitive diagnosis of primary melanoma of the submandibular gland. Moreover, no evidence of distant osteometastasis was observed in whole-body scans. Subsequent surgical management with the approach of excising the submandibular salivary gland and concurrent selective neck dissection was implemented. Conclusions This report emphasizes the importance of thorough examination and prompt referral to designated specialists in cases with suspicious behaviors which are unresponsive to treatments. It can be further concluded that melanoma can mimic a range of benign pathologies; therefore, putting it in the list differential diagnosis of similar lesions seems plausible. |
| first_indexed | 2024-12-10T19:53:25Z |
| format | Article |
| id | doaj.art-d323436f8e1749749a5e350146b4370f |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-12-10T19:53:25Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-d323436f8e1749749a5e350146b4370f2022-12-22T01:35:43ZengBMCBMC Oral Health1472-68312022-08-012211710.1186/s12903-022-02380-2Primary melanoma of submandibular gland: case report and literature review of a very rare entityHassan Mir Mohammad Sadeghi0Ramtin Dastgir1Shaghayegh Bozorg Zadeh2Fatemeh Mashhadiabbas3Abbas Karimi4Meysam Mohammadi Khah5Department of Oral and Maxillofacial Surgery, School of Dentistry, Shahid Beheshti University of Medical SciencesFaculty of Dentistry, Tehran Medical Sciences, Islamic Azad UniversityDepartment of Oral and Maxillofacial Surgery, Taleghani Hospital, Mazandaran University of Medical SciencesDepartment of Oral and Maxillofacial Pathology, Dental School, Shahid Beheshti University of Medical SciencesDepartment of Oral and Maxillofacial Surgery, Dental School, Tehran University of Medical SciencesDepartment of Oral and Maxillofacial Surgery, School of Dentistry, Shahid Beheshti University of Medical SciencesAbstract Background Cutaneous melanomas account for more than 95% of all cases of primary melanoma, making non-cutaneous primary melanomas truly rare. Cases of primary mucosal melanomas of the oral cavity have been widely described; however, instances of primary melanomas arising from salivary glands have been rarely described. To date, this is only the second case of primary melanoma of the submandibular gland. Case presentation This is a report of a case of a 36-year-old healthy male patient, who was referred to us with the chief complaint of a growing swelling on the left side of his lower jaw. Evaluations revealed an evident facial asymmetry in the frontal view with a firm, non-tender swelling. Initial orthopantomogram did not reveal any alterations in the trabeculation or morphology of the jaws and the surrounding structures. A soft tissue ultrasonography of the left submandibular gland and anterior region of mandible revealed a hypoechoic cystic mass with numerous micro-echoes. Further para-clinical examinations yielded the definitive diagnosis of primary melanoma of the submandibular gland. Moreover, no evidence of distant osteometastasis was observed in whole-body scans. Subsequent surgical management with the approach of excising the submandibular salivary gland and concurrent selective neck dissection was implemented. Conclusions This report emphasizes the importance of thorough examination and prompt referral to designated specialists in cases with suspicious behaviors which are unresponsive to treatments. It can be further concluded that melanoma can mimic a range of benign pathologies; therefore, putting it in the list differential diagnosis of similar lesions seems plausible.https://doi.org/10.1186/s12903-022-02380-2Primary melanomaNeoplasmTumorSubmandibular glandCase report |
| spellingShingle | Hassan Mir Mohammad Sadeghi Ramtin Dastgir Shaghayegh Bozorg Zadeh Fatemeh Mashhadiabbas Abbas Karimi Meysam Mohammadi Khah Primary melanoma of submandibular gland: case report and literature review of a very rare entity BMC Oral Health Primary melanoma Neoplasm Tumor Submandibular gland Case report |
| title | Primary melanoma of submandibular gland: case report and literature review of a very rare entity |
| title_full | Primary melanoma of submandibular gland: case report and literature review of a very rare entity |
| title_fullStr | Primary melanoma of submandibular gland: case report and literature review of a very rare entity |
| title_full_unstemmed | Primary melanoma of submandibular gland: case report and literature review of a very rare entity |
| title_short | Primary melanoma of submandibular gland: case report and literature review of a very rare entity |
| title_sort | primary melanoma of submandibular gland case report and literature review of a very rare entity |
| topic | Primary melanoma Neoplasm Tumor Submandibular gland Case report |
| url | https://doi.org/10.1186/s12903-022-02380-2 |
| work_keys_str_mv | AT hassanmirmohammadsadeghi primarymelanomaofsubmandibularglandcasereportandliteraturereviewofaveryrareentity AT ramtindastgir primarymelanomaofsubmandibularglandcasereportandliteraturereviewofaveryrareentity AT shaghayeghbozorgzadeh primarymelanomaofsubmandibularglandcasereportandliteraturereviewofaveryrareentity AT fatemehmashhadiabbas primarymelanomaofsubmandibularglandcasereportandliteraturereviewofaveryrareentity AT abbaskarimi primarymelanomaofsubmandibularglandcasereportandliteraturereviewofaveryrareentity AT meysammohammadikhah primarymelanomaofsubmandibularglandcasereportandliteraturereviewofaveryrareentity |