5-AZA Upregulates SOCS3 and PTPN6/SHP1, Inhibiting STAT3 and Potentiating the Effects of AG490 against Primary Effusion Lymphoma Cells

5-AZA Upregulates SOCS3 and PTPN6/SHP1, Inhibiting STAT3 and Potentiating the Effects of AG490 against Primary Effusion Lymphoma Cells

Epigenetic modifications, including aberrant DNA methylation occurring at the promoters of oncogenes and oncosuppressor genes and histone modifications, can contribute to carcinogenesis. Aberrant methylation mediated by histone methylatransferases, alongside histones, can affect methylation of prote...

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Bibliographic Details
Main Authors: Michele Di Crosta, Andrea Arena, Rossella Benedetti, Maria Saveria Gilardini Montani, Mara Cirone
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Current Issues in Molecular Biology
Subjects:
STAT3
PEL
5-Azacytidine
AG490
valemetostat
Online Access:https://www.mdpi.com/1467-3045/46/3/156

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