Immunosuppressive capacity of circulating MDSC predicts response to immune checkpoint inhibitors in melanoma patients

Immunosuppressive capacity of circulating MDSC predicts response to immune checkpoint inhibitors in melanoma patients

PurposeAlthough the treatment of advanced melanoma patients with immune checkpoint inhibitors (ICI) significantly increased the therapeutic efficiency, many patients remain resistant to ICI that could be due to immunosuppression mediated by myeloid-derived suppressor cells (MDSC). These cells are en...

Full description

Bibliographic Details
Main Authors: Vera Petrova, Christopher Groth, Rebekka Bitsch, Ihor Arkhypov, Sonja C. S. Simon, Svetlana Hetjens, Verena Müller, Jochen Utikal, Viktor Umansky
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
MDSC
melanoma
immunosuppression
immune checkpoint inhibitors
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1065767/full

Similar Items

Similar Items