Identification of human monoclonal antibodies specific for human SOD1 recognizing distinct epitopes and forms of SOD1.

Identification of human monoclonal antibodies specific for human SOD1 recognizing distinct epitopes and forms of SOD1.

Mutations in the gene encoding human SOD1 (hSOD1) can cause amyotrophic lateral sclerosis (ALS) yet the mechanism by which mutant SOD1 can induce ALS is not fully understood. There is currently no cure for ALS or treatment that significantly reduces symptoms or progression. To develop tools to under...

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Bibliographic Details
Main Authors: Teresa J Broering, Hongyan Wang, Naomi K Boatright, Yang Wang, Katherine Baptista, Gilda Shayan, Kerry A Garrity, Can Kayatekin, Daryl A Bosco, C Robert Matthews, Donna M Ambrosino, Zuoshang Xu, Gregory J Babcock
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3629177?pdf=render

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