Circulation of single serotype of Dengue Virus (DENV-3) in New Delhi, India during 2016: A change in the epidemiological trend
Background: Dengue is a rapidly emerging arthropod borne viral infection affecting tropical and sub-tropical regions of the world. Dengue is an acute febrile illness but sometimes causes more fatal complications like dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS). Delhi, the capital...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-01-01
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| Series: | Journal of Infection and Public Health |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034118301370 |
| _version_ | 1818336640381222912 |
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| author | Nazish Parveen Arshi Islam Ayesha Tazeen Malik Hisamuddin Mohd Abdullah Irshad H. Naqvi Md I. Faizan Divya Gulyani Anwar Ahmed Shama Parveen |
| author_facet | Nazish Parveen Arshi Islam Ayesha Tazeen Malik Hisamuddin Mohd Abdullah Irshad H. Naqvi Md I. Faizan Divya Gulyani Anwar Ahmed Shama Parveen |
| author_sort | Nazish Parveen |
| collection | DOAJ |
| description | Background: Dengue is a rapidly emerging arthropod borne viral infection affecting tropical and sub-tropical regions of the world. Dengue is an acute febrile illness but sometimes causes more fatal complications like dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS). Delhi, the capital of India has become hyper endemic for dengue virus because all the four serotypes are circulating here. Methods: The present study describes the identification of dengue virus from clinical samples collected from the suspected dengue patients from New Delhi, India during 2016. The CprM region of Dengue virus genome was analyzed for phylogenetic, selection pressure and Shannon entropy analyses. Results: The present study reports circulation of a single serotype (DENV-3) in New Delhi, during 2016. The phylogenetic analysis revealed that Indian subcontinent (genotype III) of DENV-3 was circulating in Delhi during this period. Neutral selection pressure in the analyzed region revealed relatively conserved nature of this part of the Dengue virus genome. Amino acid at 31 was positively selected and had high entropy value suggesting probability of variation at this position. Conclusions: The changing trend in circulation of dengue virus serotypes necessitates the continuous epidemiological surveillance for the dengue outbreaks in this region. Keywords: Dengue virus, Epidemiology, Phylogenetic analysis, Selection pressure, Entropy analysis |
| first_indexed | 2024-12-13T14:42:32Z |
| format | Article |
| id | doaj.art-d327988cea9e40798c4aeee7a2083850 |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-12-13T14:42:32Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-d327988cea9e40798c4aeee7a20838502022-12-21T23:41:35ZengElsevierJournal of Infection and Public Health1876-03412019-01-011214956Circulation of single serotype of Dengue Virus (DENV-3) in New Delhi, India during 2016: A change in the epidemiological trendNazish Parveen0Arshi Islam1Ayesha Tazeen2Malik Hisamuddin3Mohd Abdullah4Irshad H. Naqvi5Md I. Faizan6Divya Gulyani7Anwar Ahmed8Shama Parveen9Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, IndiaCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, IndiaCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, IndiaCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India; School of Basic and Life Sciences, Jaipur National University, Jaipur, IndiaCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India; School of Basic and Life Sciences, Jaipur National University, Jaipur, IndiaDr. M.A. Ansari Health Centre, Jamia Millia Islamia, New Delhi, IndiaCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, IndiaCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, IndiaDepartment of Biochemistry, King Saud University, Riyadh, Saudi Arabia; Centre for Excellence in Biotechnology Research, Department of Biochemistry, King Saud University, Riyadh, Saudi ArabiaCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India; Corresponding author.Background: Dengue is a rapidly emerging arthropod borne viral infection affecting tropical and sub-tropical regions of the world. Dengue is an acute febrile illness but sometimes causes more fatal complications like dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS). Delhi, the capital of India has become hyper endemic for dengue virus because all the four serotypes are circulating here. Methods: The present study describes the identification of dengue virus from clinical samples collected from the suspected dengue patients from New Delhi, India during 2016. The CprM region of Dengue virus genome was analyzed for phylogenetic, selection pressure and Shannon entropy analyses. Results: The present study reports circulation of a single serotype (DENV-3) in New Delhi, during 2016. The phylogenetic analysis revealed that Indian subcontinent (genotype III) of DENV-3 was circulating in Delhi during this period. Neutral selection pressure in the analyzed region revealed relatively conserved nature of this part of the Dengue virus genome. Amino acid at 31 was positively selected and had high entropy value suggesting probability of variation at this position. Conclusions: The changing trend in circulation of dengue virus serotypes necessitates the continuous epidemiological surveillance for the dengue outbreaks in this region. Keywords: Dengue virus, Epidemiology, Phylogenetic analysis, Selection pressure, Entropy analysishttp://www.sciencedirect.com/science/article/pii/S1876034118301370 |
| spellingShingle | Nazish Parveen Arshi Islam Ayesha Tazeen Malik Hisamuddin Mohd Abdullah Irshad H. Naqvi Md I. Faizan Divya Gulyani Anwar Ahmed Shama Parveen Circulation of single serotype of Dengue Virus (DENV-3) in New Delhi, India during 2016: A change in the epidemiological trend Journal of Infection and Public Health |
| title | Circulation of single serotype of Dengue Virus (DENV-3) in New Delhi, India during 2016: A change in the epidemiological trend |
| title_full | Circulation of single serotype of Dengue Virus (DENV-3) in New Delhi, India during 2016: A change in the epidemiological trend |
| title_fullStr | Circulation of single serotype of Dengue Virus (DENV-3) in New Delhi, India during 2016: A change in the epidemiological trend |
| title_full_unstemmed | Circulation of single serotype of Dengue Virus (DENV-3) in New Delhi, India during 2016: A change in the epidemiological trend |
| title_short | Circulation of single serotype of Dengue Virus (DENV-3) in New Delhi, India during 2016: A change in the epidemiological trend |
| title_sort | circulation of single serotype of dengue virus denv 3 in new delhi india during 2016 a change in the epidemiological trend |
| url | http://www.sciencedirect.com/science/article/pii/S1876034118301370 |
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