Applications of T1 and T2 relaxation time calculation in tissue differentiation and cancer diagnostics—a systematic literature review
IntroductionThe purpose of this review was to summarize current applications of non-contrast-enhanced quantitative magnetic resonance imaging (qMRI) in tissue differentiation, considering healthy tissues as well as comparisons of malignant and benign samples. The analysis concentrates mainly on the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1010643/full |
| _version_ | 1811191456422952960 |
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| author | Marta Micek David Aebisher Justyna Surówka Dorota Bartusik-Aebisher Michał Madera |
| author_facet | Marta Micek David Aebisher Justyna Surówka Dorota Bartusik-Aebisher Michał Madera |
| author_sort | Marta Micek |
| collection | DOAJ |
| description | IntroductionThe purpose of this review was to summarize current applications of non-contrast-enhanced quantitative magnetic resonance imaging (qMRI) in tissue differentiation, considering healthy tissues as well as comparisons of malignant and benign samples. The analysis concentrates mainly on the epithelium and epithelial breast tissue, especially breast cancer.MethodsA systematic review has been performed based on current recommendations by publishers and foundations. An exhaustive overview of currently used techniques and their potential in medical sciences was obtained by creating a search strategy and explicit inclusion and exclusion criteria.Results and DiscussionPubMed and Elsevier (Scopus & Science Direct) search was narrowed down to studies reporting T1 or T2 values of human tissues, resulting in 404 initial candidates, out of which roughly 20% were found relevant and fitting the review criteria. The nervous system, especially the brain, and connective tissue such as cartilage were the most frequently analyzed, while the breast remained one of the most uncommon subjects of studies. There was little agreement between published T1 or T2 values, and methodologies and experimental setups differed strongly. Few contemporary (after 2000) resources have been identified that were dedicated to studying the relaxation times of tissues and their diagnostic applications. Most publications concentrate on recommended diagnostic standards, for example, breast acquisition of T1- or T2-weighted images using gadolinium-based contrast agents. Not enough data is available yet to decide how repeatable or reliable analysis of relaxation times is in diagnostics, so it remains mainly a research topic. So far, qMRI might be recommended as a diagnostic help providing general insight into the nature of lesions (benign vs. malignant). However, additional means are generally necessary to differentiate between specific lesion types. |
| first_indexed | 2024-04-11T15:05:30Z |
| format | Article |
| id | doaj.art-d328b01103914b3d97023b1ca3b5078e |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T15:05:30Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-d328b01103914b3d97023b1ca3b5078e2022-12-22T04:16:49ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-11-011210.3389/fonc.2022.10106431010643Applications of T1 and T2 relaxation time calculation in tissue differentiation and cancer diagnostics—a systematic literature reviewMarta Micek0David Aebisher1Justyna Surówka2Dorota Bartusik-Aebisher3Michał Madera4SoftSystem Sp. z o.o, Rzeszow, PolandDepartment of Photomedicine and Physical Chemistry, Medical College of The University of Rzeszow, Rzeszow, PolandSoftSystem Sp. z o.o, Rzeszow, PolandDepartment of Biochemistry and General Chemistry, Medical College of The University of Rzeszow, Rzeszow, PolandSoftSystem Sp. z o.o, Rzeszow, PolandIntroductionThe purpose of this review was to summarize current applications of non-contrast-enhanced quantitative magnetic resonance imaging (qMRI) in tissue differentiation, considering healthy tissues as well as comparisons of malignant and benign samples. The analysis concentrates mainly on the epithelium and epithelial breast tissue, especially breast cancer.MethodsA systematic review has been performed based on current recommendations by publishers and foundations. An exhaustive overview of currently used techniques and their potential in medical sciences was obtained by creating a search strategy and explicit inclusion and exclusion criteria.Results and DiscussionPubMed and Elsevier (Scopus & Science Direct) search was narrowed down to studies reporting T1 or T2 values of human tissues, resulting in 404 initial candidates, out of which roughly 20% were found relevant and fitting the review criteria. The nervous system, especially the brain, and connective tissue such as cartilage were the most frequently analyzed, while the breast remained one of the most uncommon subjects of studies. There was little agreement between published T1 or T2 values, and methodologies and experimental setups differed strongly. Few contemporary (after 2000) resources have been identified that were dedicated to studying the relaxation times of tissues and their diagnostic applications. Most publications concentrate on recommended diagnostic standards, for example, breast acquisition of T1- or T2-weighted images using gadolinium-based contrast agents. Not enough data is available yet to decide how repeatable or reliable analysis of relaxation times is in diagnostics, so it remains mainly a research topic. So far, qMRI might be recommended as a diagnostic help providing general insight into the nature of lesions (benign vs. malignant). However, additional means are generally necessary to differentiate between specific lesion types.https://www.frontiersin.org/articles/10.3389/fonc.2022.1010643/fullMRIcancerdiagnosticsT1 relaxation timeT2 relaxation time |
| spellingShingle | Marta Micek David Aebisher Justyna Surówka Dorota Bartusik-Aebisher Michał Madera Applications of T1 and T2 relaxation time calculation in tissue differentiation and cancer diagnostics—a systematic literature review Frontiers in Oncology MRI cancer diagnostics T1 relaxation time T2 relaxation time |
| title | Applications of T1 and T2 relaxation time calculation in tissue differentiation and cancer diagnostics—a systematic literature review |
| title_full | Applications of T1 and T2 relaxation time calculation in tissue differentiation and cancer diagnostics—a systematic literature review |
| title_fullStr | Applications of T1 and T2 relaxation time calculation in tissue differentiation and cancer diagnostics—a systematic literature review |
| title_full_unstemmed | Applications of T1 and T2 relaxation time calculation in tissue differentiation and cancer diagnostics—a systematic literature review |
| title_short | Applications of T1 and T2 relaxation time calculation in tissue differentiation and cancer diagnostics—a systematic literature review |
| title_sort | applications of t1 and t2 relaxation time calculation in tissue differentiation and cancer diagnostics a systematic literature review |
| topic | MRI cancer diagnostics T1 relaxation time T2 relaxation time |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1010643/full |
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