The Incidence of Hyponatraemia and Its Effect on the ECOG Performance Status among Lung Cancer Patients
Context: Hyponatraemia is one of the common electrolytic disorders which are associated with lung cancer. Hyponatraemia may influence the ECOG performance status at presentation. Also, to the best of our knowledge, we found only limited Indian studies where the ECOG score was correlated with the...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2013-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/3225/42-%205900_PF1(M)_E(C)_F(T)_F1(V)_F1(T)_PF1(PRP)_PFA(PR)_PF3_(PUH)_B.pdf |
| Summary: | Context: Hyponatraemia is one of the common electrolytic
disorders which are associated with lung cancer. Hyponatraemia
may influence the ECOG performance status at presentation.
Also, to the best of our knowledge, we found only limited Indian
studies where the ECOG score was correlated with the serum
sodium status in lung cancer patients on presentation.
Aim: To assess the incidence of hyponatraemia among the
patients of carcinoma of the lung before putting them into the
specific treatment category for cancer and to check the effects
on their ECOG performance status.
Settings and Design: A cross–sectional, observational study was
conducted on 116 consecutive patients of lung cancer during the
period from November 2011 to October 2012.
Material and Methods: The patients with a histologically proven
diagnosis of lung cancer were grouped initially according to their
ECOG performance statuses. The serum sodium value of each
patient was measured and the hyponatraemic patients were given
treatment according to the protocol. The correlation of the ECOG
performance status with the serum sodium of the lung cancer
patients was measured. To check for any laboratory error in
serum sodium, we selected (n = 58) age, sex and socioeconomic
matched control patients.
Results: At presentation 44.8% of the lung cancer patients
showed hyponatraemia [52/116]. The ECOG score was
significantly poor in the advanced clinical stages (ECOG ≤2 Vs
ECOG ≥ 3 in NSCLC cases, c2 =11.25, P=.0008). The ECOG
performance status score at admission showed a negative
correlation with the serum sodium status which was measured on
admission among all the patients (Pearson correlation coefficient
= – 0.186). The clinical stage of the lung cancer also showed
a positive correlation with the ECOG score at admission in our
study (Pearson correlation coefficient = 0.295).
Conclusion: Hyponatraemia is not an uncommon condition and
it should be suspected and screened in each patient, as it may
influence the ECOG performance status score, which serves as
an important factor in the prognosis of lung cancer. |
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| ISSN: | 2249-782X 0973-709X |