Immunosuppression status of liver transplant recipients with hepatitis C affects biopsy-proven acute rejection
Background/Aims The relationship between patient survival and biopsy-proven acute rejection (BPAR) in liver transplant recipients with hepatitis C remains unclear. The aims of this study were to compare the characteristics of patients with and without BPAR and to identify risk factors for BPAR. Meth...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Association for the Study of the Liver
2016-09-01
|
| Series: | Clinical and Molecular Hepatology |
| Subjects: | |
| Online Access: | http://e-cmh.org/upload/pdf/cmh-2016-0022.pdf |
| _version_ | 1828185134219657216 |
|---|---|
| author | Jong Man Kim Kwang-Woong Lee Gi-Won Song Bo-Hyun Jung Hae Won Lee Nam-Joon Yi ChoonHyuck David Kwon Shin Hwang Kyung-Suk Suh Jae-Won Joh Suk-Koo Lee Sung-Gyu Lee |
| author_facet | Jong Man Kim Kwang-Woong Lee Gi-Won Song Bo-Hyun Jung Hae Won Lee Nam-Joon Yi ChoonHyuck David Kwon Shin Hwang Kyung-Suk Suh Jae-Won Joh Suk-Koo Lee Sung-Gyu Lee |
| author_sort | Jong Man Kim |
| collection | DOAJ |
| description | Background/Aims The relationship between patient survival and biopsy-proven acute rejection (BPAR) in liver transplant recipients with hepatitis C remains unclear. The aims of this study were to compare the characteristics of patients with and without BPAR and to identify risk factors for BPAR. Methods We retrospectively reviewed the records of 169 HCV-RNA-positive patients who underwent LT at three centers. Results BPAR occurred in 39 (23.1%) of the HCV-RNA-positive recipients after LT. The 1-, 3-, and 5-year survival rates were 92.1%, 90.3%, and 88.5%, respectively, in patients without BPAR, and 75.7%, 63.4%, and 58.9% in patients with BPAR (P<0.001). Multivariate analyses showed that BPAR was associated with the non-use of basiliximab and tacrolimus and the use of cyclosporin in LT recipients with HCV RNA-positive. Conclusion The results of the present study suggest that the immunosuppression status of HCV-RNA-positive LT recipients should be carefully determined in order to prevent BPAR and to improve patient survival. |
| first_indexed | 2024-04-12T06:59:38Z |
| format | Article |
| id | doaj.art-d32acc0458574d2bba8b64b2e54f74ca |
| institution | Directory Open Access Journal |
| issn | 2287-2728 2287-285X |
| language | English |
| last_indexed | 2024-04-12T06:59:38Z |
| publishDate | 2016-09-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj.art-d32acc0458574d2bba8b64b2e54f74ca2022-12-22T03:43:03ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2016-09-0122336637110.3350/cmh.2016.00221315Immunosuppression status of liver transplant recipients with hepatitis C affects biopsy-proven acute rejectionJong Man Kim0Kwang-Woong Lee1Gi-Won Song2Bo-Hyun Jung3Hae Won Lee4Nam-Joon Yi5ChoonHyuck David Kwon6Shin Hwang7Kyung-Suk Suh8Jae-Won Joh9Suk-Koo Lee10Sung-Gyu Lee11 Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine; Seoul, Korea Department of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Surgery, Seoul National University Boramae Medical Center, Seoul, Korea Department of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine; Seoul, Korea Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine; Seoul, Korea Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine; Seoul, Korea Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaBackground/Aims The relationship between patient survival and biopsy-proven acute rejection (BPAR) in liver transplant recipients with hepatitis C remains unclear. The aims of this study were to compare the characteristics of patients with and without BPAR and to identify risk factors for BPAR. Methods We retrospectively reviewed the records of 169 HCV-RNA-positive patients who underwent LT at three centers. Results BPAR occurred in 39 (23.1%) of the HCV-RNA-positive recipients after LT. The 1-, 3-, and 5-year survival rates were 92.1%, 90.3%, and 88.5%, respectively, in patients without BPAR, and 75.7%, 63.4%, and 58.9% in patients with BPAR (P<0.001). Multivariate analyses showed that BPAR was associated with the non-use of basiliximab and tacrolimus and the use of cyclosporin in LT recipients with HCV RNA-positive. Conclusion The results of the present study suggest that the immunosuppression status of HCV-RNA-positive LT recipients should be carefully determined in order to prevent BPAR and to improve patient survival.http://e-cmh.org/upload/pdf/cmh-2016-0022.pdfHepatitis C virusImmunosuppressionRejectionOutcomeCalcineurin antagonistsTacrolimus |
| spellingShingle | Jong Man Kim Kwang-Woong Lee Gi-Won Song Bo-Hyun Jung Hae Won Lee Nam-Joon Yi ChoonHyuck David Kwon Shin Hwang Kyung-Suk Suh Jae-Won Joh Suk-Koo Lee Sung-Gyu Lee Immunosuppression status of liver transplant recipients with hepatitis C affects biopsy-proven acute rejection Clinical and Molecular Hepatology Hepatitis C virus Immunosuppression Rejection Outcome Calcineurin antagonists Tacrolimus |
| title | Immunosuppression status of liver transplant recipients with hepatitis C affects biopsy-proven acute rejection |
| title_full | Immunosuppression status of liver transplant recipients with hepatitis C affects biopsy-proven acute rejection |
| title_fullStr | Immunosuppression status of liver transplant recipients with hepatitis C affects biopsy-proven acute rejection |
| title_full_unstemmed | Immunosuppression status of liver transplant recipients with hepatitis C affects biopsy-proven acute rejection |
| title_short | Immunosuppression status of liver transplant recipients with hepatitis C affects biopsy-proven acute rejection |
| title_sort | immunosuppression status of liver transplant recipients with hepatitis c affects biopsy proven acute rejection |
| topic | Hepatitis C virus Immunosuppression Rejection Outcome Calcineurin antagonists Tacrolimus |
| url | http://e-cmh.org/upload/pdf/cmh-2016-0022.pdf |
| work_keys_str_mv | AT jongmankim immunosuppressionstatusoflivertransplantrecipientswithhepatitiscaffectsbiopsyprovenacuterejection AT kwangwoonglee immunosuppressionstatusoflivertransplantrecipientswithhepatitiscaffectsbiopsyprovenacuterejection AT giwonsong immunosuppressionstatusoflivertransplantrecipientswithhepatitiscaffectsbiopsyprovenacuterejection AT bohyunjung immunosuppressionstatusoflivertransplantrecipientswithhepatitiscaffectsbiopsyprovenacuterejection AT haewonlee immunosuppressionstatusoflivertransplantrecipientswithhepatitiscaffectsbiopsyprovenacuterejection AT namjoonyi immunosuppressionstatusoflivertransplantrecipientswithhepatitiscaffectsbiopsyprovenacuterejection AT choonhyuckdavidkwon immunosuppressionstatusoflivertransplantrecipientswithhepatitiscaffectsbiopsyprovenacuterejection AT shinhwang immunosuppressionstatusoflivertransplantrecipientswithhepatitiscaffectsbiopsyprovenacuterejection AT kyungsuksuh immunosuppressionstatusoflivertransplantrecipientswithhepatitiscaffectsbiopsyprovenacuterejection AT jaewonjoh immunosuppressionstatusoflivertransplantrecipientswithhepatitiscaffectsbiopsyprovenacuterejection AT sukkoolee immunosuppressionstatusoflivertransplantrecipientswithhepatitiscaffectsbiopsyprovenacuterejection AT sunggyulee immunosuppressionstatusoflivertransplantrecipientswithhepatitiscaffectsbiopsyprovenacuterejection |