| Summary: | Purpose This study aimed to investigate the correlation between the fat signal fraction (FF) of the fatdominant
bone tissue of the knee joint, measured using the MRI Dixon method (DIXON) technique,
and bone mineral density (BMD).
Materials and Methods Among the patients who underwent knee DIXON imaging at our institute,
we retrospectively analyzed 93 patients who also underwent dual energy X-ray absorptiometry within
1 year. The FFs of the distal femur metaphyseal (Fm) and proximal tibia metaphyseal (Tm) were calculated
from the DIXON images, and the correlation between FF and BMD was analyzed. Patients were
grouped based on BMD of lumbar spine (L), femoral neck (FN), and common femur (FT) respectively,
and the Kruskal-Wallis H test was performed for FF.
Results We identified a significant negative correlation between TmFF and FN-BMD in the entire patient
group (r = -0.26, p < 0.05). In female patients, TmFF showed a negative correlation with FN-BMD, FT-BMD, and L-BMD (r = -0.38, 0.28 and -0.27, p < 0.05). In male patients, FmFF was negatively correlated
with only FN-BMD and FT-BMD (r = -0.58 and -0.42, p < 0.05). There was a significant difference in
the TmFF between female patients grouped by BMD (p < 0.05). In male patients, there was a significant
difference in FmFF (p < 0.05).
Conclusion Overall, we found that FF and BMD around the knee joints showed a negative correlation.
This suggests the potential of FF measurement using DIXON for BMD screening.
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